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Merck
CN

I1762

伊索昔康

analytical standard

别名:

4-Hydroxy-2-methyl-N-5-methyl-3-isoxolyl-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide

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关于此项目

经验公式(希尔记法):
C14H13N3O5S
化学文摘社编号:
分子量:
335.34
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
252-084-5
MDL number:
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产品名称

伊索昔康, analytical standard

InChI key

YYUAYBYLJSNDCX-UHFFFAOYSA-N

InChI

1S/C14H13N3O5S/c1-8-7-11(16-22-8)15-14(19)12-13(18)9-5-3-4-6-10(9)23(20,21)17(12)2/h3-7,18H,1-2H3,(H,15,16,19)

SMILES string

CN1C(C(=O)Nc2cc(C)on2)=C(O)c3ccccc3S1(=O)=O

grade

analytical standard

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

Quality Level

Gene Information

Application

Isoxicam may be used as an internal standard for the quantification of meloxicam in pharmaceutical preparations and as an analytical reference standard for the quantification of the analyte in biological samples using different analytical techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

General description

Isoxicam is a long acting anti-inflammatory agent belonging to the oxicam group, and helps in relieving the symptoms of degenerative joint disease and rheumatoid arthritis. Its mode of action involves the ability to inhibit prostaglandin synthesis by suppressing the formation of cyclooxygenase and subsequent prostaglandin.

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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E M Grace et al.
Current medical research and opinion, 10(9), 580-591 (1987-01-01)
Nineteen patients, aged 60 years and over, with rheumatoid arthritis participated in a clinical trial to investigate the pharmacokinetics of isoxicam (a new non-steroidal anti-inflammatory drug) in this age group. The purpose of the study was to determine if the
Oxicams: metabolic disposition in man and animals.
T F Woolf et al.
Drug metabolism reviews, 21(2), 255-276 (1989-01-01)
M Esquivel et al.
Clinical and investigative medicine. Medecine clinique et experimentale, 10(5), 363-367 (1987-09-01)
To determine the effect of liver dysfunction on the absorption and disposition of isoxicam, we administered a single oral dose of 200 mg to 8 patients with alcoholic cirrhosis, and followed the plasma concentration-time curve for 96 h. The calculated
M Tariq
Research communications in chemical pathology and pharmacology, 60(1), 19-25 (1988-04-01)
The protective effect of some novel nonsteroidal anti-inflammatory agents has been studied on the endotoxin (lipopolysaccharide B) shock induced mortality in mice and biochemical changes in rats. All the three compounds included in this report, namely isoxicam, fentiazac and ketoprofen
Flow injection chemiluminescence determination of isoxicam based on diperiodatoargentate (III)-fluorescein system in a micellar medium
Zhao F and Si H
Journal of Luminescence, 135(1), 259-264 (2013)

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