I4386
Iodoacetic acid
≥98.0% (T)
Synonym(s):
2-Iodoacetic acid
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About This Item
Linear Formula:
ICH2CO2H
CAS Number:
Molecular Weight:
185.95
UNSPSC Code:
12352106
NACRES:
NA.77
PubChem Substance ID:
EC Number:
200-590-1
Beilstein/REAXYS Number:
1739079
MDL number:
Quality Segment
biological source
synthetic
assay
≥98.0% (T)
form
powder or flakes
color
white to yellow
mp
77-79 °C (lit.)
solubility
H2O: soluble, clear to hazy
storage temp.
−20°C
SMILES string
OC(=O)CI
InChI
1S/C2H3IO2/c3-1-2(4)5/h1H2,(H,4,5)
InChI key
JDNTWHVOXJZDSN-UHFFFAOYSA-N
Application
Iodoacetic acid has been used as an alkylating agent for antibody AR37, serum proteins and strawberry proteome samples extracted from different stages of ripened fruit.
Reagent for the modification of cysteine residues in proteins.
Biochem/physiol Actions
Iodoacetic acid (IAA) blocks the thiol group of cysteine. IAA inhibits glyceraldehyde-3-phosphate dehydrogenase (G3PDH) by interacting with sulfhydryl group of the active site cysteine. IAA inhibits the progression of solid Ehrlich carcinoma. IAA is one of the iodinated disinfection byproducts in drinking water. It is cytotoxic to mammalian cells.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Eye Dam. 1 - Skin Corr. 1A
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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