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I8000010

Ivermectin

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

22,23-Dihydroavermectin B1, MK-933

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About This Item

CAS Number:
70288-86-7
NACRES:
NA.24
PubChem Substance ID:
329815318
UNSPSC Code:
41116107
MDL number:
MFCD00869511

Key Documents

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Product Name

Ivermectin, European Pharmacopoeia (EP) Reference Standard

InChI

1S/C48H74O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3/b13-12+,27-15+,32-14+/t25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+/m0/s1

SMILES string

[H][C@@]1(O[C@]2(CC[C@@H]1C)C[C@@H]3C[C@@H](C\C=C(C)\[C@@H](O[C@H]4C[C@H](OC)[C@@H](O[C@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)[C@@H](C)\C=C\C=C6/CO[C@]7([H])[C@H](O)C(C)=C[C@@H](C(=O)O3)[C@]67O)O2)[C@@H](C)CC

InChI key

AZSNMRSAGSSBNP-XPNPUAGNSA-N

grade

pharmaceutical primary standard

API family

ivermectin

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

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Related Categories

Application

Ivermectin EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

signalword

Danger

Hazard Classifications

Acute Tox. 1 Oral - Acute Tox. 3 Dermal - Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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I Jana I Janssen et al.
Experimental parasitology, 134(2), 171-177 (2013-03-23)
P-glycoproteins (Pgps) are members of the ABC transporter superfamily and are involved in detoxification mechanisms of single- and multicellular organisms. Their importance for survival of organisms in the presence of harmful drug concentrations has been widely studied in cancer cells
James Whitehorn et al.
The Southeast Asian journal of tropical medicine and public health, 44(2), 179-181 (2013-05-23)
Ivermectin has been shown in in vitro studies to have insecticidal properties against Aedes aegypti adults. This study aimed to assess these properties in vivo. Aedes aegypti survival was not affected by acquiring a blood meal from humans both 5
Sklice (ivermectin) lotion for the treatment of head lice.
Noah Scheinfeld
Skinmed, 11(3), 171-172 (2013-08-13)
Scientists celebrate successes, new tools in fight against human parasitic worms.
Bridget M Kuehn
JAMA, 310(1), 19-20 (2013-07-04)
Topical ivermectin lotion for head lice.
Olivier Chosidow et al.
The New England journal of medicine, 368(10), 968-968 (2013-03-09)
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