LIGHTOX26
LightOx™26
≥95% (HPLC)
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About This Item
Empirical Formula (Hill Notation):
C23H27NO2
CAS Number:
Molecular Weight:
349.47
UNSPSC Code:
12352101
NACRES:
NA.22
assay
≥95% (HPLC)
form
powder
storage temp.
2-8°C
SMILES string
N1(CCC(c2c1ccc(c2)c3ccc(cc3)\C=C\C(=O)O)(C)C)C(C)C
InChI key
CBXGBVMKROHWAL-KPKJPENVSA-N
Application
Fluorescence microscopy, fluorescent retinoid binding assay, fluorescence spectroscopy.
Biochem/physiol Actions
Strong ligand for retinoic acid receptor proteins
Features and Benefits
LightOx26 is a synthetic analogue of all-trans-retinoic acid (ATRA), that exhibits solvatochromatic fluorescence emission when excited with UV or 405 nm light. The compound is a strong ligand for the retinoic acid receptor proteins (RARs) and related cellular retinoic acid binding proteins (CRABPI/II) and can, therefore, be used as a replacement for ATRA in cellular assays involving retinoid signaling processes. LightOx26 can be utilised to study retinoid behaviour using fluorescence microscopy, employed in a competitive fluorometric ligand-binding assay for direct determination of the strength of binding of non-fluorescent retinoids to a protein target, and as a fluorophore in fluorescence spectroscopy.
Product can be used with our line of photoreactors: Including Penn PhD (Z744035) & SynLED 2.0 (Z744080)
Product can be used with our line of photoreactors: Including Penn PhD (Z744035) & SynLED 2.0 (Z744080)
Other Notes
Chemical Equivalency 1ea=1mg
Legal Information
LightOx is a trademark of LightOx Ltd.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Articles
Fluorescent retinoic acid analogues for use in cellular imaging, protein-ligand binding assays, and flow cytometry to bypass traditional problems associated with fluorescent probes.