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M0200000

Mannitol

European Pharmacopoeia (EP) Reference Standard

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Synonym(s):
D-Mannitol, Mannite
Empirical Formula (Hill Notation):
C6H14O6
CAS Number:
Molecular Weight:
182.17
Beilstein:
1721898
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

mannitol

manufacturer/tradename

EDQM

mp

167-170 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

InChI

1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1

InChI key

FBPFZTCFMRRESA-KVTDHHQDSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets, has been developed and issued under the Authority of the Issuing Pharmacopoeia.

For further information and support please go to the website of the issuing Pharmacopoeia.

Application

This European Pharmacopoeia reference standard is intended for use only as specifically prescribed in the European Pharmacopoeia. Their suitability for any other use is not guaranteed and is the sole responsibility of the user. This standard is not intended for human or animal use.
Established for the preparation of the below-given solutions as per European Pharmacopoeia:

  • Reference solution (b) in the testing of related substances using liquid chromatography (General text 2.2.29) in isomalt, according to the monograph 1531
  • Reference solutions (a) in the identification of mannitol using thin-layer chromatography (General text 2.2.27) and infra-red spectroscopy and testing of related substances and assay using liquid chromatography (General text 2.2.29), according to the monograph 0559
  • Reference solution (b) in the identification of sorbitol using thin-layer chromatography (General text 2.2.27), according to the monograph 0435
  • Reference solution (b) in the testing of related substances using gas chromatography (General text 2.2.28), according to the monograph 1381

Biochem/physiol Actions

A sugar alcohol sweet tastant. Used in sweetness inhibition studies.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1


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Xylitol
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 4223-4225 (2016)
Sorbitol
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 3865-3867 (2019)
Isomalt
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 2998-2999 (2019)
Mannitol
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 3175-3176 (2019)
Heikki O Koskela et al.
Chest, 124(6), 2171-2177 (2003-12-11)
To compare a new bronchial provocation test, the mannitol challenge, with cold air and histamine challenges to demonstrate airway hyperresponsiveness (AHR) in patients with difficult-to-diagnose asthma. A prospective study. Thirty-seven consecutive patients with recently diagnosed, steroid-naive, mild, or atypical asthma

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