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M8277

Midodrine hydrochloride

Name: Midodrine hydrochloride
Brand: SIAL

analytical standard, for drug analysis

Synonym(s):

(±)-1-(2,5-Dimethoxyphenyl)-2-glycinamidoethanol

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About This Item

Empirical Formula (Hill Notation):

C₁₂H₁₈N₂O₄ · HCl

CAS Number:

3092-17-9

Molecular Weight:

290.74

NACRES:

NA.24

PubChem Substance ID:

329818055

UNSPSC Code:

41116107

MDL number:

MFCD00079455

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Properties

Quality Level

100

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

Cl.COc1ccc(OC)c(c1)C(O)CNC(=O)CN

InChI

1S/C12H18N2O4.ClH/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13;/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16);1H

InChI key

MGCQZNBCJBRZDT-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)

Description

General description

Midodrine is a prodrug and a long acting α-adrenergic stimulating agent, and forms an active metabolite, desglymidodrine, which causes an elevation of the systemic blood pressure with the reduction in heart rate.

Application

Midodrine hydrochloride may be used as an analytical reference standard for the quantification of the analyte in biological samples and pharmaceutical formulations using different chromatography techniques.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

α-Adrenergic agonist; vasoconstrictor

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pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P301 + P310

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Regulatory Information

监管及禁止进口产品

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Stability indicating RP-HPLC assay method for estimation of midodrine hydrochloride in bulk and tablets

Jain.KH, et al.

International Journal of Pharmacy and Pharmaceutical Sciences, 9(9), 283-287 (2016)

Midodrine hydrochloride and the treatment of orthostatic hypotension in tetraplegia: two cases and a review of the literature.

D B Barber et al.

Spinal cord, 38(2), 109-111 (2000-04-13)

A report of two cases of orthostatic hypotension in acute tetraplegia that were resistant to classic treatment interventions. To discuss the use of midodrine hydrochloride for the treatment of orthostatic hypotension in early tetraplegia. Department of Rehabilitation Medicine, The University

The Orthostatic Hypotension Questionnaire (OHQ): validation of a novel symptom assessment scale.

Horacio Kaufmann et al.

Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 22(2), 79-90 (2011-11-03)

There is no widely accepted validated scale to assess the comprehensive symptom burden and severity of neurogenic orthostatic hypotension (NOH). The Orthostatic Hypotension Questionnaire (OHQ) was developed, with two components: the six-item symptoms assessment scale and a four-item daily activity

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Global Trade Item Number

SKU	GTIN
M8277-1G	04061826762257
M8277-50MG	04061833652596