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M8640

1-Methoxy-5-methylphenazinium methyl sulfate

Name: 1-Methoxy-5-methylphenazinium methyl sulfate
Brand: SIAL

≥95% purity , powder

Synonym(s):

1-Methoxyphenazine methosulfate

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About This Item

Empirical Formula (Hill Notation):

C₁₅H₁₆N₂O₅S

CAS Number:

65162-13-2

Molecular Weight:

336.36

NACRES:

NA.47

PubChem Substance ID:

329818065

UNSPSC Code:

12171500

EC Number:

265-579-6

MDL number:

MFCD00040648

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Product Name

1-Methoxy-5-methylphenazinium methyl sulfate, ≥95%

Quality Level

200

assay

≥95%

form

powder

composition

Nitrogen: ≥ 7.9%

technique(s)

titration: suitable

color

red to brown

solubility

H₂O: 1 mg/mL, clear, red

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

COS([O-])(=O)=O.COc1cccc2[n+](C)c3ccccc3nc12

InChI

1S/C14H13N2O.CH4O4S/c1-16-11-7-4-3-6-10(11)15-14-12(16)8-5-9-13(14)17-2;1-5-6(2,3)4/h3-9H,1-2H3;1H3,(H,2,3,4)/q+1;/p-1

InChI key

MASUWVVNWALEEM-UHFFFAOYSA-M

Related Categories

Clinical & Diagnostics

Hematology Stains

Histology Stains

Tissue Diagnostics

General description

1-Methoxy-5-methylphenazinium methyl sulfate (MPMS) is a photochemically stable electron-transport mediator between NAD(P)H and tetrazolium dyes. The reduced form of MPMS converts tetrazolium salt to purple precipitate formazan.It is a very stable and non-enzymic electron carrier that mediates electron transfer by dehydrogenases in vitro to various electron acceptors such as tetrazolium dyes or the electrode of an enzymic electric cell.

Application

1-Methoxy-5-methylphenazinium methyl sulfate has been used as a component of buffers or solutions for the assay of lactate dehydrogenase and muscle succinate dehydrogenase.

pictograms

GHS08,GHS07

signalword

Warning

hcodes

H302,H315,H319,H341,H351,H361d,H373

pcodes

P202 - P260 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Muta. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 2

target_organs

Nervous system

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Cell surface oxygen consumption: a major contributor to cellular oxygen consumption in glycolytic cancer cell lines.

Patries M Herst et al.

Biochimica et biophysica acta, 1767(2), 170-177 (2007-02-03)

Oxygen consumption for bioenergetic purposes has long been thought to be the prerogative of mitochondria. Nevertheless, mitochondrial gene knockout (rho(0)) cells that are defective in mitochondrial respiration require oxygen for growth and consume oxygen at the cell surface via trans-plasma

Use of 1-methoxy-5-methylphenazinium methyl sulfate (1-methoxyPMS) in the assay of some enzymes of diagnostic importance.

S Nakamura et al.

Clinica chimica acta; international journal of clinical chemistry, 101(2-3), 321-326 (1980-02-28)

1-Methoxy-5-methylphenazinium methyl sulfate (1-methoxyPMS) is a photochemically stable electron mediator between NAD(P)H and tetrazolium dyes. We have examined the efficiency of 1-methoxyPMS as an electron mediator in the assay of human lactate dehydrogenase (LDH, EC 1.1.1.27) and the activity staining

An optimized lactate dehydrogenase release assay for screening of drug candidates in neuroscience.

Kaja S, et. al.

Journal of Pharmacological and Toxicological Methods, 73, 1-1 (2015)

Development of a synchronous enzyme-reaction system for a highly sensitive enzyme immunoassay.

Kuniyo Inouye et al.

Journal of biochemistry, 131(1), 97-105 (2002-01-05)

A synchronous enzyme-reaction system using water-soluble formazan and a non-enzymatic electron mediator was developed and applied to an enzyme immunoassay (EIA). The reaction system consists of four steps: (I) dephosphorylation of NADP(+) to produce NAD(+) by alkaline phosphatase (ALP), (II)

Acid-specific formaldehyde donor is a potential, dual targeting cancer chemotherapeutic/chemo preventive drug for FANC/BRCA-mutant cancer.

John R Ridpath et al.

Genes and environment : the official journal of the Japanese Environmental Mutagen Society, 41, 23-23 (2020-01-01)

Development of chemotherapeutic/preventive drugs that selectively kill cancer - the Holy Grail of cancer research - is a major challenge. A particular difficulty arises when chemotherapeutics and radiation are found to be rather ineffective against quiescent cancer cells in solid

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Global Trade Item Number

SKU	GTIN
M8640-100MG	04061834063421
M8640-500MG	04061832343631

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