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About This Item
Empirical Formula (Hill Notation):
C6H5NO2
CAS Number:
Molecular Weight:
123.11
Beilstein:
109591
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24
biological source
synthetic
grade
pharmaceutical primary standard
Agency
EP
API family
nicotinic acid
form
solid
manufacturer/tradename
EDQM
technique(s)
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
mp
236-239 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
SMILES string
OC(=O)c1cccnc1
InChI
1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)
InChI key
PVNIIMVLHYAWGP-UHFFFAOYSA-N
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General description
Nicotinic acid is a type of vitamin B that is effective against dyslipidemia. It can also be potentially used as a peripheral vasodilator.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Nicotinic acid may be used as an EP reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Other Notes
Sales restrictions may apply.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
379.4 °F - closed cup
Flash Point(C)
193 °C - closed cup
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Simultaneous Estimation of Meclizine Hydrochloride and Nicotinic Acid in Pharmaceutical Dosage form by RP-HPLC Method
REDDY S, et al.
Asian Journal of Pharmaceutical Research and Health Care, 5(2) (2013)
Development and optimisation of a generic micellar electrokinetic capillary chromatography method to support analysis of a wide range of pharmaceuticals and excipients
Altria KD and McLean R
Journal of Pharmaceutical and Biomedical Analysis, 18(4-5), 807-813 (1998)
Nicotinic acid
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 5(2), 4961-4962 (2017)
RP-HPLC method for the determination of atorvastatin calcium and nicotinic acid in combined tablet dosage form
Shah DA, et al.
Indian Journal of Pharmaceutical Sciences, 69(5), 700-700 (2007)
Janet E Digby et al.
Arteriosclerosis, thrombosis, and vascular biology, 32(3), 582-588 (2011-12-31)
Niacin has been used for more than 50 years in the treatment of cardiovascular disease, although its use has largely been superseded by better-tolerated lipid-modulating interventions. There has been a renewed interest in the HDL-cholesterol raising properties of niacin, with
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