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Merck
CN

N0800000

Nikethamide

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

N,N-Diethylnicotinamide, Nicotinic acid diethylamide, Nikethamide

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About This Item

Empirical Formula (Hill Notation):
C10H14N2O
CAS Number:
59-26-7
Molecular Weight:
178.23
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329818462
MDL number:
MFCD00006386
Beilstein/REAXYS Number:
5743

Key Documents

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InChI

1S/C10H14N2O/c1-3-12(4-2)10(13)9-6-5-7-11-8-9/h5-8H,3-4H2,1-2H3

SMILES string

CCN(CC)C(=O)c1cccnc1

InChI key

NCYVXEGFNDZQCU-UHFFFAOYSA-N

grade

pharmaceutical primary standard

API family

nikethamide

manufacturer/tradename

EDQM

refractive index

n20/D 1.524 (lit.)

bp

296-300 °C (lit.)

mp

23 °C (lit.)

density

1.06 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

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Application

Nikethamide EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301,H319

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

235.4 °F - closed cup

flash_point_c

113 °C - closed cup

Regulatory Information

监管及禁止进口产品
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Determination of nikethamide and N-ethylnicotinamide in the blood and urine of greyhounds.
Lewis J H.
Journal of Chromatography A, 172, 295-302 (1979)
Lili Chen et al.
Journal of pharmaceutical and biomedical analysis, 43(5), 1757-1762 (2007-02-10)
Nikethamide and lidocaine are often requested to be quantified simultaneously in forensic toxicological analysis. A simple reversed-phase high performance liquid chromatography (RP-HPLC) method has been developed for their simultaneous determination in human blood and cerebrospinal fluid. The method involves simple
Nathaly Reyes-Garcés et al.
Journal of chromatography. A, 1374, 40-49 (2014-12-03)
Simple, fast and efficient sample preparation approaches that allow high-throughput isolation of various compounds from complex matrices are highly desired in bioanalysis. Particularly sought are methods that can, without sacrificing time, easily remove matrix interferences capable of inducing ionization suppression/enhancement

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