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Merck
CN

N5410

Nicotinic acid

meets USP testing specifications

Synonym(s):

3-Picolinic acid, Niacin, Pellagra preventive factor, Pyridine-3-carboxylic acid, Vitamin B3

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About This Item

Empirical Formula (Hill Notation):
C6H5NO2
CAS Number:
59-67-6
Molecular Weight:
123.11
UNSPSC Code:
12352106
NACRES:
NA.21
PubChem Substance ID:
24897734
EC Number:
200-441-0
Beilstein/REAXYS Number:
109591
MDL number:
MFCD00006391

Key Documents

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Product Name

Nicotinic acid, meets USP testing specifications

InChI key

PVNIIMVLHYAWGP-UHFFFAOYSA-N

InChI

1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)

SMILES string

OC(=O)c1cccnc1

biological source

synthetic (organic)

agency

USP/NF
meets USP testing specifications

assay

99.0-101.0% dry basis

form

powder

color

white

mp

236-239 °C (lit.)

application(s)

pharmaceutical (small molecule)

Quality Level

200

Gene Information

human ... CYP1A2(1544)
rat ... Chrnb2(54239)

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Application

Nicotinic acid has been used as an antioxidant to evaluate its protective functionality in colon LoVo cell lines against doxorubicin induced cytotoxicity.

Biochem/physiol Actions

Nicotinic modulates lipid metabolism and may be useful in treating dyslipidemia. It is an antioxidant and acts as a coenzyme in the form of nicotinamide adenine nucleotides. Deficiency of niacin leads to enhanced lipid peroxidation and is also implicated in Crohn′s disease Deficiency also impacts DNA repair and also leads to skin and gastrointestinal disorder, pellagra. Nicotinic acid reduces the low-density lipoprotein (LDL) synthesis and improves high-density lipoprotein (HDL) levels.

General description

Nicotinic acid, also referred to as niacin or as vitamin B3, is a water-soluble vitamin. Nicotinic acid is synthesized from the amino acid tryptophan and is present majorly in peanuts, fish and lean meat.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

379.4 °F - closed cup

flash_point_c

193 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000352084
0000352084
0000350315
0000350315
SLCG7372

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Effect of pO2 on antitumor drug cytotoxicity on MDR and non-MDR variants selected from the LoVo metastatic colon carcinoma cell line
Lelong-Rebel I, et al.
Anticancer Research, 28(1A), 55-68 (2008)
Pellagra: a non-eradicated old disease
Savvidou S
Clinics and practice, 4(1) (2014)
Niacin deficiency delays DNA excision repair and increases spontaneous and nitrosourea-induced chromosomal instability in rat bone marrow
Kostecki LM
Mutation Research. Fundamental and Molecular Mechanisms of Mutagenesis, 625(1-2), 50-61 (2007)
Nicotinic acid: an old drug with a promising future
Bodor ET and Offermanns S
British Journal of Pharmacology, 153(S1), S68-S75 (2008)
Nicotinic acid: a lipid-lowering agent with unrealized potential
Aboulsoud SH
The Egyptian Journal of Internal Medicine, 26(1), 1-1 (2014)
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