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Merck
CN

O4755

Oxantel pamoate

analytical standard

Synonym(s):

1-Methyl-2-(3-hydroxyphenylethenyl)-1,4,5,6-tetrahydropyrimidine compound with 4,4′-methylenebis(3-hydroxy-2-naphthoic acid), Oxantel embonate

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About This Item

Empirical Formula (Hill Notation):
C13H16N2O · C23H16O6
CAS Number:
68813-55-8
Molecular Weight:
604.65
NACRES:
NA.24
PubChem Substance ID:
329818912
UNSPSC Code:
41116107
EC Number:
272-332-6
MDL number:
MFCD19105662

Key Documents

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Product Name

Oxantel pamoate, analytical standard

InChI key

CCOAINFUFGBHBA-UETGHTDLSA-N

InChI

1S/C23H16O6.C13H16N2O/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29;1-15-9-3-8-14-13(15)7-6-11-4-2-5-12(16)10-11/h1-10,24-25H,11H2,(H,26,27)(H,28,29);2,4-7,10,16H,3,8-9H2,1H3/b;7-6+

SMILES string

CN1CCCN=C1\C=C\c2cccc(O)c2.OC(=O)c3cc4ccccc4c(Cc5c(O)c(cc6ccccc56)C(O)=O)c3O

grade

analytical standard

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

Quality Level

200

Related Categories

Application

Oxantel pamoate may be used as a reference standard for examining the quality of pharmaceutical dosage forms containing oxantel pamoate (OPA) by reversed-phase high-performance liquid chromatography method.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

General description

Oxantel pamoate is a drug used in the treatment of trichuriasis which is highly effective against the helminth of Trichuris sp.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

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K Peldán et al.
Scandinavian journal of infectious diseases, 14(4), 297-299 (1982-01-01)
166 patients with trichuriasis have been treated at the Department of Tropical Diseases, Aurora Hospital, Helsinki, from January 1975 to October 1979. Final results could be confirmed in 141 patients. Thiabendazole was found discouraging, because of frequent side effects and
G R Rajasekariah et al.
International journal for parasitology, 21(6), 697-702 (1991-10-01)
The common anthelmintics, oxantel, mebendazole, albendazole and pyrantel were assessed for their comparative activity against Trichuris muris in mice. Mice were infected with T. muris and the infection was maintained by a brief cortisone administration during the second week of
Development and validation of a RP-HPLC method for quality control of oxantel pamoate, pyrantel pamoat and praziquantel in tablets.
Tatar E, et al.
Marmara Pharmaceutical Journal (2015)
Development of oxantel tablets for pediatric clinical studies: a technical note.
Alles R, et al.
Journal of drug delivery science and technology, 23(6), 623-625 (2013)
Beatrice Barda et al.
The Lancet. Infectious diseases, 18(8), 864-873 (2018-06-03)
The recommended anthelmintics show low efficacy in a single-dose regimen against Trichuris trichiura. Moxidectin, a new treatment for river blindness, might complement the drug armamentarium for the treatment and control of soil-transmitted helminthiasis. However, its efficacy against T trichiura has
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