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Merck
CN

P0972

Sigma-Aldrich

Polymyxin B sulfate

meets USP testing specifications

Synonym(s):

Polymyxin B sulfate salt

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Estimated to ship on2025年10月09日Details


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1 EA
¥4,939.66

About This Item

Empirical Formula (Hill Notation):
C55H96N16O13 · 2H2SO4
CAS Number:
Molecular Weight:
1385.61
EC Number:
MDL number:
UNSPSC Code:
12352209
NACRES:
NA.21

¥4,939.66


Estimated to ship on2025年10月09日Details


Request a Bulk Order

Agency

USP/NF
meets USP testing specifications

Quality Level

form

powder

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria
fungi

application(s)

pharmaceutical (small molecule)

Mode of action

cell membrane | interferes

storage temp.

2-8°C

SMILES string

O=C(C(NC(C(CCN)NC(CCCCC(C)CC)=O)=O)C(C)O)NC(CCN)C(NC(CCNC(C(NC(C(NC(C(CCN)N1)=O)CCN)=O)C(O)C)=O)C(NC(CCN)C(NC(CC2=CC=CC=C2)C(NC(CC(C)C)C1=O)=O)=O)=O)=O.O=S(O)(O)=O

InChI

1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)

InChI key

HNDFYNOVSOOGDU-UHFFFAOYSA-N

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This Item
GF01949081GF03146318GF10944457
镍 rod, 50 mm diameter, length 25 mm, purity 99%

GF48507745

镍 rod, 1.5 mm diameter, length 200 mm, purity 99%

GF01949081

镍 rod, 1.5 mm diameter, length 500 mm, purity 99%

GF03146318

镍 rod, 1.5 mm diameter, length 100 mm, purity 99%

GF10944457

assay

99%

assay

99%

assay

99%

assay

99%

manufacturer/tradename

Goodfellow 485-077-45

manufacturer/tradename

Goodfellow 019-490-81

manufacturer/tradename

Goodfellow 031-463-18

manufacturer/tradename

Goodfellow 109-444-57

form

rod

form

rod

form

rod

form

rod

density

8.9 g/mL at 25 °C (lit.)

density

8.9 g/mL at 25 °C (lit.)

density

8.9 g/mL at 25 °C (lit.)

density

8.9 g/mL at 25 °C (lit.)

bp

2732 °C (lit.)

bp

2732 °C (lit.)

bp

2732 °C (lit.)

bp

2732 °C (lit.)

resistivity

6.97 μΩ-cm, 20°C

resistivity

6.97 μΩ-cm, 20°C

resistivity

6.97 μΩ-cm, 20°C

resistivity

6.97 μΩ-cm, 20°C

General description

Chemical structure: peptide

Application

Polymyxin B sulfate is a strongly cationic cyclic polypeptide antibiotic that is derived from fermentation of Bacilus polymyxa. It is a mixture of B1 and B2 sulfate. The product has been used clinically to treat infections of the urinary tract, meninges and blood stream caused by susceptible strains of Pseudomonas aeruginosa. It also has uses studying multidrug-resistant pathogens, as an immobilized agent for removal of endotoxins, and to induce pore formation in the membranes of cortex cells from excised sorghum roots.

Biochem/physiol Actions

Mode of Action: Polymyxin B Sulfate binds to the lipid A portion of bacterial lipopolysaccharides†, disrupting the cytoplasmic membrane by inducing pores large enough to permit nucleotide leakage in bacterial walls. This disrupts the permeability of the cytoplasmic membrane.

Antimicrobial spectrum: Has bactericidal action on most gram-negative bacilli††, including E. Coli and on most fungi and gram-positive bacteria.

Packaging

This product is packaged in a bottomless glass bottle, with its contents inside an inserted fused cone.

Caution

As supplied, the product should be stored at 2-8°C in the dark. No change was observed in retained samples after three years′ of storage in these conditions. Stock solutions should be sterile filtered and stored at 2-8°C. They are stable at 37°C for 5 days.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

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Handa SS and Sharma A.
The Indian Journal of Medical Research, 92, 276-283 (1990)
Activity of andrographolide against dengue virus.
Panraksa P, et al.
Antiviral Research, 139, 69-78 (2017)
Andrographolide, a potential cancer therapeutic agent isolated from Andrographis paniculata.
Rajagopal S, et al.
Journal of Experimental Therapeutics & Oncology, 3(3), 147-158 (2003)
Wan J Lu et al.
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Andrographolide, a novel nuclear factor-κB (NF-κB) inhibitor, is isolated from leaves of Andrographis paniculata. Platelet activation is relevant to a variety of coronary heart diseases. Our recent studies revealed that andrographolide possesses potent antiplatelet activity by activating the endothelial nitric

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