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P0972

多粘菌素 B 硫酸酯

Name: 多粘菌素 B 硫酸酯
Brand: SIAL

meets USP testing specifications

别名:

多粘菌素 B 硫酸盐

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About This Item

经验公式（希尔记法）:

C₅₅H₉₆N₁₆O₁₃ · 2H₂SO₄

CAS Number:

1405-20-5

分子量:

1385.61

EC 号:

215-774-7

MDL编号:

MFCD00131991

UNSPSC代码:

12352209

NACRES:

NA.21

Agency

USP/NF
meets USP testing specifications

质量水平

200

表单

powder

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria
fungi

应用

pharmaceutical (small molecule)

作用机制

cell membrane | interferes

储存温度

2-8°C

SMILES字符串

O=C(C(NC(C(CCN)NC(CCCCC(C)CC)=O)=O)C(C)O)NC(CCN)C(NC(CCNC(C(NC(C(NC(C(CCN)N1)=O)CCN)=O)C(O)C)=O)C(NC(CCN)C(NC(CC2=CC=CC=C2)C(NC(CC(C)C)C1=O)=O)=O)=O)=O.O=S(O)(O)=O

InChI

1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)

InChI key

HNDFYNOVSOOGDU-UHFFFAOYSA-N

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一般描述

Chemical structure: peptide

应用

Polymyxin B sulfate is a strongly cationic cyclic polypeptide antibiotic that is derived from fermentation of Bacilus polymyxa. It is a mixture of B1 and B2 sulfate. The product has been used clinically to treat infections of the urinary tract, meninges and blood stream caused by susceptible strains of Pseudomonas aeruginosa. It also has uses studying multidrug-resistant pathogens, as an immobilized agent for removal of endotoxins, and to induce pore formation in the membranes of cortex cells from excised sorghum roots.

生化/生理作用

作用机制：多粘菌素B硫酸盐结合到细菌脂多糖的脂质部分†上，通过诱导足够大的孔来破坏细胞质膜，使核苷酸泄漏到细菌的细胞壁中。这可破环细胞质膜的半透性。

抗菌谱：对大多数革兰氏阴性杆菌，包括 大肠杆菌 ，真菌和革兰氏阳性菌都有杀菌作用。

包装

This product is packaged in a bottomless glass bottle, with its contents inside an inserted fused cone.

注意

As supplied, the product should be stored at 2-8°C in the dark. No change was observed in retained samples after three years′ of storage in these conditions. Stock solutions should be sterile filtered and stored at 2-8°C. They are stable at 37°C for 5 days.