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P1061

Proadifen hydrochloride

analytical standard, ≥95%

Synonym(s):

α-Phenyl-α-propylbenzeneacetic acid 2-(diethylamino)ethyl ester, N,N-Diethylaminoethyl 2,2-diphenylvalerate, SKF-525A

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About This Item

Empirical Formula (Hill Notation):
C23H31NO2 · HCl
CAS Number:
62-68-0
Molecular Weight:
389.96
NACRES:
NA.24
PubChem Substance ID:
329820069
UNSPSC Code:
41116107
MDL number:
MFCD00055151
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grade

analytical standard

Quality Level

200

assay

≥95%

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

122-123 °C

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

storage temp.

−20°C

SMILES string

Cl.CCCC(C(=O)OCCN(CC)CC)(c1ccccc1)c2ccccc2

InChI

1S/C23H31NO2.ClH/c1-4-17-23(20-13-9-7-10-14-20,21-15-11-8-12-16-21)22(25)26-19-18-24(5-2)6-3;/h7-16H,4-6,17-19H2,1-3H3;1H

InChI key

FHIKZROVIDCMJA-UHFFFAOYSA-N

Gene Information

human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)

Application

Proadifen hydrochloride may be used as an internal standard in the determination of analgesic agents like O-desmethyltramadol, tramadol and N-desmethyltramadol in human urine samples using gas chromatography coupled with mass spectrometry (GC-MS).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Blocks glibenclamide-sensitive K+ channels. Inhibits neuronal nitric oxide synthase and cytochrome P450

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000520156
0000520156
0000496660
0000496660
0000346068

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David Fuchs et al.
Biochimica et biophysica acta. Molecular and cell biology of lipids, 1865(4), 158611-158611 (2020-01-10)
Trihydroxyoctadecenoic acids (TriHOMEs) are linoleic acid-derived lipid mediators reported to be dysregulated in obstructive lung disease. In contrast to many other oxylipins, TriHOME biosynthesis in humans is still poorly understood. The association of TriHOMEs with inflammation prompted the current investigation
Amber Woodard et al.
AIMS neuroscience, 6(1), 25-42 (2020-04-29)
Neuronal nitric oxide (nNO) has been shown to affect motor function in the brain. Specifically, nNO acts in part through regulation of dopamine (DA) release, transporter function, and the elicitation of neuroprotection/neurodegeneration of neurons in conditions such as Parkinson's disease
Simultaneous determination of tramadol, O-desmethyltramadol and N-desmethyltramadol in human urine by gas chromatography?mass spectrometry
El-Sayed Y A-A, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 926, 9-15 (2013)
View All Related Papers

Global Trade Item Number

SKUGTIN
P1061-500MG04061833285206
P1061-100MG04061833285190