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Merck
CN

P1600000

Physostigmine salicylate

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Eserine salicylate salt, Physostigmine salicylate salt

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About This Item

Empirical Formula (Hill Notation):
C15H21N3O2 · C7H6O3
CAS Number:
57-64-7
Molecular Weight:
413.47
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329820099
MDL number:
MFCD00135659
Beilstein/REAXYS Number:
3900576

Key Documents

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Product Name

Physostigmine salicylate, European Pharmacopoeia (EP) Reference Standard

InChI

1S/C15H21N3O2.C7H6O3/c1-15-7-8-17(3)13(15)18(4)12-6-5-10(9-11(12)15)20-14(19)16-2;8-6-4-2-1-3-5(6)7(9)10/h5-6,9,13H,7-8H2,1-4H3,(H,16,19);1-4,8H,(H,9,10)/t13-,15+;/m1./s1

SMILES string

OC(=O)c1ccccc1O.CNC(=O)Oc2ccc3N(C)[C@H]4N(C)CC[C@@]4(C)c3c2

InChI key

HZOTZTANVBDFOF-PBCQUBLHSA-N

grade

pharmaceutical primary standard

API family

physostigmine

manufacturer/tradename

EDQM

mp

181-183 °C

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

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Related Categories

Application

Physostigmine salicylate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Acetylcholinesterase inhibitor that crosses the blood-brain barrier and forms a carbamylated enzyme complex with acetyl cholinesterase that degrades slowly.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

涉药品监管产品
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Marcello Costa et al.
American journal of physiology. Gastrointestinal and liver physiology, 318(1), G99-G108 (2019-11-12)
Cyclical propagating waves of muscle contraction have been recorded in isolated small intestine or colon, referred to here as motor complexes (MCs). Small intestinal and colonic MCs are neurogenic, occur at similar frequencies, and propagate orally or aborally. Whether they

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