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Merck
CN

P2125

D-Pantethine

analytical standard

Synonym(s):

Bis(N-pantothenylamidoethyl) disulfide, LBF factor, Pantethein oxidized form

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About This Item

Empirical Formula (Hill Notation):
C22H42N4O8S2
CAS Number:
Molecular Weight:
554.72
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
240-842-8
MDL number:
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InChI key

DJWYOLJPSHDSAL-ROUUACIJSA-N

InChI

1S/C22H42N4O8S2/c1-21(2,13-27)17(31)19(33)25-7-5-15(29)23-9-11-35-36-12-10-24-16(30)6-8-26-20(34)18(32)22(3,4)14-28/h17-18,27-28,31-32H,5-14H2,1-4H3,(H,23,29)(H,24,30)(H,25,33)(H,26,34)/t17-,18-/m0/s1

SMILES string

CC(C)(CO)[C@@H](O)C(=O)NCCC(=O)NCCSSCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)CO

biological source

synthetic (organic)

grade

analytical standard

assay

≥90%

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

color

white

application(s)

forensics and toxicology
veterinary
vitamins, nutraceuticals, and natural products

format

neat

storage temp.

2-8°C

Quality Level

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Silvia Rubio et al.
Plant physiology, 140(3), 830-843 (2006-01-18)
Once the plant coenzyme A (CoA) biosynthetic pathway has been elucidated by comparative genomics, it is feasible to analyze the physiological relevance of CoA biosynthesis in plant life. To this end, we have identified and characterized Arabidopsis (Arabidopsis thaliana) T-DNA
J I Clark et al.
Experimental eye research, 62(1), 75-84 (1996-01-01)
Pantethine and the amino phosphorothioate, WR-77913, protected lenses against increased light scattering and opacification during cataract formation in five animal models: (1) radiation, (2) selenite, (3) galactose, (4) streptozotocin and (5) Royal College of Surgeons. In the radiation or selenite
Marie-France Penet et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(4), 1321-1326 (2008-01-16)
We report that administration of the low-molecular-weight thiol pantethine prevented the cerebral syndrome in Plasmodium berghei ANKA-infected mice. The protection was associated with an impairment of the host response to the infection, with in particular a decrease of circulating microparticles
H Nomura et al.
Clinical therapeutics, 18(3), 477-482 (1996-05-01)
We compared the efficacy of two antihyperlipidemic drugs and the efficacy of diet plus exercise therapy in the treatment of patients with moderate hypercholesterolemia. The study included 48 patients with moderate hypercholesterolemia (serum total cholesterol [TC], 250 to 320 mg/dL).
John I Clark
Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 368(1617), 20120104-20120104 (2013-03-27)
Cataract, neurodegenerative disease, macular degeneration and pathologies of ageing are often characterized by the slow progressive destabilization of proteins and their self-assembly to amyloid-like fibrils and aggregates. During normal cell differentiation, protein self-assembly is well established as a dynamic mechanism

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