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Merck
CN

P4722

Sigma-Aldrich

Pyridoxine hydrochloride

meets USP testing specifications

Synonym(s):

Adermine hydrochloride, PN HCl, Pyridoxol hydrochloride, Vitamin B6 hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C8H11NO3 · HCl
CAS Number:
58-56-0
Molecular Weight:
205.64
Beilstein:
3632435
EC Number:
200-386-2
MDL number:
MFCD00012807
UNSPSC Code:
12352205
eCl@ss:
34058008
PubChem Substance ID:
24898493
NACRES:
NA.21

Key Documents

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biological source

synthetic (organic)

Quality Level

200

Agency

USP/NF
meets USP testing specifications

Assay

98.0-102.0% dry basis

form

powder

color

white

mp

214-215 °C (lit.)

application(s)

pharmaceutical (small molecule)

SMILES string

Cl[H].Cc1ncc(CO)c(CO)c1O

InChI

1S/C8H11NO3.ClH/c1-5-8(12)7(4-11)6(3-10)2-9-5;/h2,10-12H,3-4H2,1H3;1H

InChI key

ZUFQODAHGAHPFQ-UHFFFAOYSA-N

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General description

Vitamin B group is water-soluble and exists in six forms namely the pyridoxal, pyridoxine, pyridoxamine, pyridoxamine 5′-phosphate, pyridoxine 5′-phosphate and pyridoxal 5′-phosphate. The food sources of vitamin B6 include grains, nuts, fruits, vegetables and meat.

Application

Pyridoxine hydrochloride has been used to test its neuroprotective functionality in traumatic brain injury (TBI) rats. It has also been used as a reference standard to quantify vitamin B6 in feed and digesta samples using high-performance liquid chromatography(HPLC).

Biochem/physiol Actions

Pyridoxine plays a key role in metabolism both carbohydrates and amino acids. It supports brain development and its deficiency levels may lead to depletion of γ-aminobutyric acid (GABA) levels. Pyridoxine catalyzes the neurotransmitter biosynthesis like dopamine and serotonin. Pyridoxine in excess or deficient may lead to neuropathy.

Pictograms

Corrosion
GHS05

Signal Word

Danger

Hazard Statements

H318

Precautionary Statements

P280 - P305 + P351 + P338

Hazard Classifications

Eye Dam. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000505597
0000505596
0000505596
0000505597
0000503981

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B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin
Calderon-Ospina CA, et al.
CNS Neuroscience & Therapeutics (2019)
Pyridoxine administration improves behavioral and anatomical outcome after unilateral contusion injury in the rat
Kuypers NJ and Hoane MR
Journal of Neurotrauma, 27(7), 1275-1282 (2010)
Nutritional neuropathies
Hammond N, et al.
Neurologic Clinics, 31(2), 477-477 (2013)
Effects of forage family on apparent ruminal synthesis of B vitamins in lactating dairy cows
Castagnino DS, et al.
Journal of Dairy Science, 99(3), 1884-1894 (2016)
Determination of vitamin B6 (pyridoxine) in pharmaceutical preparations by cyclic voltammetry at a copper (II) hexacyanoferrate (III) modified carbon paste electrode
Teixeira MFS, et al.
Journal of the Brazilian Chemical Society, 14(2), 316-321 (2003)
View All Related Papers

Articles

Vitamin B6, Pyridoxal and Pyridoxine in Cell Culture

Vitamin B6's impact on serum-free cell culture systems is explored for protein manufacturing.

细胞培养中的维生素B6、吡哆醛和吡哆醇

该页面针对维生素B6、吡哆醛和吡哆醇如何影响无血清、无蛋白细胞培养系统（用于包括单克隆抗体在内的异源蛋白的生物制造）的性能提供了全面的分析。本页介绍吡哆醛、吡哆醇的体外化学和生物化学。

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