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P5288

Sigma-Aldrich

Polyvinylpyrrolidone

for molecular biology, nucleic acid hybridization tested, mol wt 360,000

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Synonym(s):
PVP, Polyvidone, Povidone
Linear Formula:
(C6H9NO)n
CAS Number:
9003-39-8
MDL number:
MFCD00149016
PubChem Substance ID:
24898616
NACRES:
NA.25

grade

for molecular biology

Quality Level

200

form

powder

mol wt

360,000

suitability

nucleic acid hybridization tested

foreign activity

Endonuclease, exonuclease, RNase, none detected

SMILES string

C=CN1CCCC1=O

InChI

1S/C6H9NO/c1-2-7-5-3-4-6(7)8/h2H,1,3-5H2

InChI key

WHNWPMSKXPGLAX-UHFFFAOYSA-N

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General description

Polyvinylpyrrolidone is a large polymer containing a carbonyl, C-N and alkyl functional groups.

Application

Polyvinylpyrrolidone has been used:
  • to perform intracytoplasmic sperm injection procedure
  • in the preparation of endophyte coating agent mixture, to coat creeping bentgrass seed
  • as a component of prehybridization solution

Biochem/physiol Actions

Polyvinylpyrrolidone can bind to polyphenol. Thus, it is known to be used for RNA isolation from plants rich in polyphenols. It is extensively used in the synthesis of nanoparticles.

Other Notes

Polyvinylpyrrolidone is a component of Denhardt′s Solution and is included at a concentration of 1% (w/v) in the standard 50X stock solution.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Blastocyst formation in in vitro fertilization versus intracytoplasmic sperm injection cycles: influence of the fertilization procedure
Van LL, et al.
Fertility and Sterility, 83(5), 1397-1403 (2005)
Relevance of in vitro agar based screens to characterize the anti-fungal activities of bacterial endophyte communities
Shehata HR, et al.
BMC Microbiology, 16(1), 8-8 (2016)
Inclusion of polyvinylpyrrolidone in the polymerase chain reaction reverses the inhibitory effects of polyphenolic contamination of RNA
Koonjul PK, et al.
Nucleic Acids Research, 27(3), 915-916 (1999)
Jan Konietzka et al.
Current biology : CB, 30(1), 1-16 (2019-12-17)
Sleep requires sleep-active neurons that depolarize to inhibit wake circuits. Sleep-active neurons are under the control of homeostatic mechanisms that determine sleep need. However, little is known about the molecular and circuit mechanisms that translate sleep need into the depolarization
Kallum M Koczkur et al.
Dalton transactions (Cambridge, England : 2003), 44(41), 17883-17905 (2015-10-06)
Colloidal synthesis offers a route to nanoparticles (NPs) with controlled composition and structural features. This Perspective describes the use of polyvinylpyrrolidone (PVP) to obtain such nanostructures. PVP can serve as a surface stabilizer, growth modifier, nanoparticle dispersant, and reducing agent.
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