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Merck
CN

P9380

Pyridoxamine dihydrochloride

analytical standard, ≥98%

Synonym(s):

4-(Aminomethyl)-5-hydroxy-6-methyl-3-pyridinemethanol dihydrochloride

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About This Item

Empirical Formula (Hill Notation):
C8H12N2O2 · 2HCl
CAS Number:
524-36-7
Molecular Weight:
241.11
Beilstein:
3632748
EC Number:
208-357-6
MDL number:
MFCD00012808
UNSPSC Code:
41116107
PubChem Substance ID:
329820346
NACRES:
NA.24

Key Documents

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biological source

synthetic (organic)

Quality Level

200

grade

analytical standard

Assay

≥98%

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

color

white to off-white

mp

224-226 °C (dec.) (lit.)

application(s)

vitamins, nutraceuticals, and natural products

format

neat

storage temp.

−20°C

SMILES string

Cl[H].Cl[H].Cc1ncc(CO)c(CN)c1O

InChI

1S/C8H12N2O2.2ClH/c1-5-8(12)7(2-9)6(4-11)3-10-5;;/h3,11-12H,2,4,9H2,1H3;2*1H

InChI key

HNWCOANXZNKMLR-UHFFFAOYSA-N

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General description

Pyridoxamine dihydrochloride is a salt and amine form of pyridoxamine, which belongs to the family of vitamin B6 compounds. Pyridoxamine occurs naturally in animal-based food products. Its deficiency in humans potentially causes sideroblastic anemia, weakness, insomnia, and neurological disorders. It has been reported to be effective against diabetic nephropathy.

Application

Pyridoxamine dihydrochloride analytical standard can be used as follows:
  • Combined analysis of eight water-soluble vitamins along with their different forms by liquid chromatography combined with isotope-dilution mass spectrometry (IDMS) in different fortified food samples
  • Simultaneous determination of eleven water-soluble B vitamins by liquid chromatography-tandem mass spectrometry (LC-MS/MS) in ultrafiltrate samples
  • Multi-residue analysis of total thiamine, total riboflavin, total pyridoxine, and total niacin in infant formula and related nutritional products by enzymatic digestion followed by LC-MS-MS determination as per AOAC Official Method 2015.14
  • LC/MS-MS based assay of seven different vitamers of vitamin B3 and vitamin B6 in 40 human hair samples

Other Notes

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
WXBF6829V
0000478375
0000478375
0000464741
0000464741

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Pyridoxamine dihydrochloride in diabetic nephropathy (PIONEER-CSG-17): lessons learned from a pilot study
Dwyer JP, et al.
Nephron, 129(1), 22-28 (2015)
Nutritional diseases
Tropical Dermatology E-Book, 407-407 (2016)
Mechanisms and regulation of intestinal absorption of water-soluble vitamins: cellular and molecular aspects
Physiology of the Gastrointestinal Tract, 407-407 (2016)
Thomas Bachmann et al.
Analytical and bioanalytical chemistry, 412(26), 7237-7252 (2020-08-17)
Vitamin B6 comprises an important set of molecules tightly interwoven with the human amino acid, fatty acid, and carbohydrate metabolism. Analytical methods striving for the quantification of individual B6 vitamers so far mostly rely on methods based on HPLC in

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