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PHR1009

Supelco

Caffeine

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
1,3,7-Trimethylxanthine
Empirical Formula (Hill Notation):
C8H10N4O2
CAS Number:
58-08-2
Molecular Weight:
194.19
Beilstein:
17705
MDL number:
MFCD00005758
PubChem Substance ID:
329823040
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to BP 766
traceable to Ph. Eur. C0100000
traceable to USP 1085003

API family

dimenhydrinate, caffeine, pentoxifylline

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

234-236.5 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

CN1C(=O)N(C)c2ncn(C)c2C1=O

InChI

1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3

InChI key

RYYVLZVUVIJVGH-UHFFFAOYSA-N

Gene Information

human ... ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140)

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General description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards. Caffeine is an N-methyl derivative of xanthine and is involved in gastric acid secretion, diuresis, and stimulation of the central nervous system.

Application

Caffeine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations, blood plasma, food, drinks, and herbal products by chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

A central nervous system stimulant believed to act through adenosine receptors and monoamine neurotransmitters. It is an adenosine receptor antagonist and adenosine 3′,5′-cyclic monophosphate (cAMP) phosphodiesterase inhibitor. Thus, levels of cAMP increase in cells following treatment with caffeine. It has been reported to affect cellular calcium levels, releasing calcium from intracellular stores. It overrides the cell cycle effects of various chemicals such as protease inhibitors, preventing apoptosis; and it has been shown to inhibit cellular DNA repair mechanisms.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB7780 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

related product

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Description
Pricing

1086006

Caffeine melting point standard, United States Pharmacopeia (USP) Reference Standard

PHR1095

Caffeine Melting Point Standard, Pharmaceutical Secondary Standard; Certified Reference Material

1085003

Caffeine, United States Pharmacopeia (USP) Reference Standard

1508901

Pentoxifylline, United States Pharmacopeia (USP) Reference Standard

C0100000

Caffeine, European Pharmacopoeia (EP) Reference Standard

P0510000

Pentoxifylline, European Pharmacopoeia (EP) Reference Standard

Y0000787

Caffeine for system suitability, European Pharmacopoeia (EP) Reference Standard

D2000000

Dimenhydrinate, European Pharmacopoeia (EP) Reference Standard

Y0001103

Dimenhydrinate for peak identification, European Pharmacopoeia (EP) Reference Standard

1206006

Dimenhydrinate, United States Pharmacopeia (USP) Reference Standard

1206017

Dimenhydrinate Related Compound E, United States Pharmacopeia (USP) Reference Standard

PHR1658

Dimenhydrinate, Pharmaceutical Secondary Standard; Certified Reference Material

BP766

Caffeine, British Pharmacopoeia (BP) Reference Standard

PHR1999

Caffeine Impurity C, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2000

Caffeine Impurity F, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1951

Caffeine Impurity E Nitrate (Caffeidine Nitrate), Pharmaceutical Secondary Standard; Certified Reference Material

PHR2038

Caffeine Impurity B, Pharmaceutical Secondary Standard; Certified Reference Material

BP1119

Diphenylmethanol, British Pharmacopoeia (BP) Reference Standard

PHR2117

4,4′-Difluorobenzophenone, Pharmaceutical Secondary Standard; Certified Reference Material

PHR3142

7-Methylxanthine, pharmaceutical secondary standard, certified reference material

PHR3218

Pentoxifylline, pharmaceutical secondary standard, certified reference material

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

监管及禁止进口产品

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Simultaneous HPLC determination of caffeine, theobromine, and theophylline in food, drinks, and herbal products.
Srdjenovic B, et al.
Journal of Chromatographic Science, 46(2), 144-149 (2008)
Simultaneous voltammetric determination of paracetamol and caffeine in pharmaceutical formulations using a boron-doped diamond electrode.
Lourenc?o BC
Talanta, 78(3), 748-752 (2009)
Simultaneous determination of caffeine and non-steroidal anti-inflammatory drugs in pharmaceutical formulations and blood plasma by reversed-phase HPLC from linear gradient elution.
Mart?n MJ, et al.
Talanta, 49(2), 453-459 (1999)
Jonathan M Hodgson et al.
The American journal of clinical nutrition, 97(5), 943-950 (2013-04-05)
Measures of blood pressure variation have been associated with cardiovascular disease and related outcomes. The regular consumption of black tea can lower blood pressure, but its effects on blood pressure variation have yet to be investigated. We aimed to assess
Nicolas Bousette et al.
Journal of cellular physiology, 229(3), 374-383 (2013-09-17)
Calnexin (CNX) is an endoplasmic reticulum (ER) quality control chaperone that has been implicated in ER stress. ER stress is a prominent pathological feature of various pathologic conditions, including cardiovascular diseases. However, the role of CNX and ER stress has
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