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PHR1012

Methylparaben

Name: Methylparaben
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):

Methyl 4-hydroxybenzoate, p-Hydroxybenzoic acid methyl ester, Methyl paraben, NIPAGIN

Linear Formula:

HOC₆H₄CO₂CH₃

CAS Number:

99-76-3

Molecular Weight:

152.15

Beilstein:

509801

EC Number:

202-785-7

MDL number:

MFCD00002352

PubChem Substance ID:

329823043

E Number:

E218

NACRES:

NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to Ph. Eur. M1650000
traceable to USP 1432005

API family

parabens

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

125-128 °C (lit.)

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care
pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

COC(=O)c1ccc(O)cc1

InChI

1S/C8H8O3/c1-11-8(10)6-2-4-7(9)5-3-6/h2-5,9H,1H3

InChI key

LXCFILQKKLGQFO-UHFFFAOYSA-N

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Related Categories

Analytical Reference Standards

Sigma-Aldrich

Certified Reference Materials

Food & Cosmetic Component Standards

Food Additive Standards

General description

Methylparaben is an antifungal and antibacterial agent, widely used as a preservative in cosmetics, pharmaceuticals, food and beverages.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Methylparaben may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using reversed-phase sequential injection chromatography (SIC) technique and high-performance liquid chromatography technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC0280 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

related product

Product No.

Description

Pricing

Hazard Classifications

Aquatic Chronic 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

334.4 °F

Flash Point(C)

168 °C

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A novel gradient HPLC method for simultaneous determination of ranitidine, methylparaben and propylparaben in oral liquid pharmaceutical formulation

Kokoletsi XM, et al.

Journal of Pharmaceutical and Biomedical Analysis, 38(4), 763-767 (2005)

Determination of ambroxol hydrochloride, methylparaben and benzoic acid in pharmaceutical preparations based on sequential injection technique coupled with monolithic column

Satinsky D, et al.

Journal of Pharmaceutical and Biomedical Analysis, 40(2), 287-293 (2006)

Simultaneous determination of methylparaben, propylparaben, hydrocortisone acetate and its degradation products in a topical cream by RP-HPLC.

Hajkova R, et al.

Journal of Pharmaceutical and Biomedical Analysis, 32(4-5), 921-927 (2003)

Mosquito larvicidal activity of methyl-p-hydroxybenzoate isolated from the leaves of Vitex trifolia Linn.

K Kannathasan et al.

Acta tropica, 120(1-2), 115-118 (2011-07-19)

The vector-borne diseases caused by mosquitoes are one of the major health problems in many countries especially in tropical and sub-tropical countries. The resistance of mosquitoes to synthetic chemicals and environmental toxicity created by the chemicals raised the demand for

New concept for HPTLC peak purity assessment and identification of drugs in multi-component mixtures.

Ismail I Hewala et al.

Talanta, 88, 623-630 (2012-01-24)

Simple methods for HPTLC peak purity assessment and identification of the HPTLC peaks were presented. The spectrodensitograms - selected at different time intervals across the elution time of the HPTLC peak - were extracted and digital algorithms for manipulating the

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