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PHR1018

Dextromethorphan HBr

Name: Dextromethorphan HBr
Brand: SIAL

certified reference material

Synonym(s):

Dextromethorphan hydrobromide monohydrate, (9S,13S,14S)-3-Methoxy-17-methylmorphinan hydrobromide

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₂₅NO · HBr · H₂O

CAS Number:

6700-34-1

Molecular Weight:

370.32

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329823049

MDL number:

MFCD02173901

Beilstein/REAXYS Number:

6453793

eCl@ss:

25140904

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Properties

grade

pharmaceutical secondary standard, certified reference material

Quality Segment

300

agency

traceable to Ph. Eur. D0740000, traceable to USP 1181007

description

Kábítószer / Narcotic Drug (Hungary), 78/2022. (XII. 28.) BM rendelet

API family

dextromethorphan

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, chromatography: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical
pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

Br[H].[H]O[H].[H][C@]12CCCC[C@]13CCN(C)[C@H]2Cc4ccc(OC)cc34

InChI

1S/C18H25NO.BrH.H2O/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18;;/h6-7,12,15,17H,3-5,8-11H2,1-2H3;1H;1H2/t15-,17+,18+;;/m1../s1

InChI key

STTADZBLEUMJRG-IKNOHUQMSA-N

Gene Information

human ... GRIN2A(2903), SIGMAR1(10280)

Description

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Dextromethorphan HBr is a cough suppressant and a mucolytic agent, widely used in the treatment of various respiratory disorders such as for the relief of non-productive cough.

Application

Dextromethorphan HBr may be used pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using hydrophilic interaction liquid chromatographic technique and first-derivative spectrophotometry technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAC0713 in the slot below. This is an example certificate only and may not be the lot that you receive.

Pictograms

GHS06,GHS09

Signal Word

Danger

Hazard Codes

H301,H411

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 2

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

Flash Point (°F)

Not applicable

Flash Point (°C)