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PHR1026

Ranitidine hydrochloride

Name: Ranitidine hydrochloride
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):

N, N Dimethyl-5-[2-(1-methylamine-2-nitrovinyl)-ethylthiomethyl]furfurylamine hydrochloride

Empirical Formula (Hill Notation):

C₁₃H₂₂N₄O₃S · HCl

CAS Number:

66357-59-3

Molecular Weight:

350.86

EC Number:

266-333-0

MDL number:

MFCD00069339

PubChem Substance ID:

329823056

NACRES:

NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to BP 471
traceable to Ph. Eur. R0150000
traceable to USP 1598405

API family

ranitidine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

Cl[H].CN\C(NCCSCc1ccc(CN(C)C)o1)=C\[N+]([O-])=O

InChI

1S/C13H22N4O3S.ClH/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3;/h4-5,9,14-15H,6-8,10H2,1-3H3;1H/b13-9-;

InChI key

GGWBHVILAJZWKJ-CHHCPSLASA-N

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Analytical Reference Standards

Sigma-Aldrich

General description

Ranitidine hydrochloride is a H₂-receptor antagonist, widely used for the management of hypersecretory conditions and for the treatment of duodenal ulcer.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Ranitidine hydrochloride may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using titrimetry and visible spectrophotometry techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

H2 histamine receptor antagonist; anti-ulcer agent.

H₂ histamine receptor antagonist; anti-ulcer agent.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA5630 in the slot below. This is an example certificate only and may not be the lot that you receive.

related product

Product No.

Description

Pricing

1598405

Ranitidine hydrochloride, United States Pharmacopeia (USP) Reference Standard

1598507

1598700

1598609

PHR1774

PHR1773

PHR1775

BP471

Ranitidine hydrochloride, British Pharmacopoeia (BP) Reference Standard

PHR2180

Ranitidine Impurity I, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2181

Ranitidine Impurity J, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2179

Ranitidine Impurity H, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2182

Ranitidine Impurity K, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2175

Ranitidine Impurity D, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2177

Ranitidine Impurity F

PHR2178

Ranitidine Impurity G, Pharmaceutical Secondary Standard; Certified Reference Material

Pictograms

GHS07,GHS08

Signal Word

Danger

Hazard Statements

H315 - H317 - H319 - H334 - H335

Precautionary Statements

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Spectrophotometric determination of ranitidine hydrochloride based on the reaction with p-dimethylaminobenzaldehyde

Narayana B, et al.

Eurasian Journal of Analytical Chemistry, 5(1), 63-72 (2010)

Bidirectional crosstalk between stress-induced gastric ulcer and depression under chronic stress.

Shuang Zhang et al.

PloS one, 7(12), e51148-e51148 (2012-12-20)

Stress contributes to a variety of diseases and disorders such as depression and peptic ulcer. The present study aimed to investigate the correlation between stress ulcer and depression in pathogenesis and treatment by using chronic stress depression (CSD), chronic psychological

Single oral doses of netazepide (YF476), a gastrin receptor antagonist, cause dose-dependent, sustained increases in gastric pH compared with placebo and ranitidine in healthy subjects.

M Boyce et al.

Alimentary pharmacology & therapeutics, 36(2), 181-189 (2012-05-23)

Nonclinical studies have shown netazepide (YF476) to be a potent, selective, competitive and orally active gastrin receptor antagonist. To administer to humans for the first time single oral doses of netazepide, to assess their tolerability, safety, pharmacokinetics and effect on

Response of chronic cough to acid-suppressive therapy in patients with gastroesophageal reflux disease.

Peter J Kahrilas et al.

Chest, 143(3), 605-612 (2012-11-03)

Epidemiologic and physiologic studies suggest an association between gastroesophageal reflux disease (GERD) and chronic cough. However, the benefit of antireflux therapy for chronic cough remains unclear, with most relevant trials reporting negative findings. This systematic review aimed to reevaluate the

Single-pass intestinal perfusion to establish the intestinal permeability of model drugs in mouse.

Elvira Escribano et al.

International journal of pharmaceutics, 436(1-2), 472-477 (2012-07-21)

The aim of the present work was to study the intestinal permeabilities (P(eff)) of five model drugs: furosemide, piroxicam, naproxen, ranitidine and amoxicillin in the in situ intestinal perfusion technique in mice and compare them with corresponding rat and human

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