All Photos(1)

Documents

PHR1059

Omeprazole

Name: Omeprazole
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

Sign Into View Organizational & Contract Pricing

All Photos(1)

Synonym(s):

5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole, Antra, Losec

Empirical Formula (Hill Notation):

C₁₇H₁₉N₃O₃S

CAS Number:

73590-58-6

Molecular Weight:

345.42

MDL number:

MFCD00083192

PubChem Substance ID:

329823089

NACRES:

NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to BP 765
traceable to Ph. Eur. O0150000
traceable to USP 1478505

API family

omeprazole

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

COc1ccc2[nH]c(nc2c1)S(=O)Cc3ncc(C)c(OC)c3C

InChI

1S/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)

InChI key

SUBDBMMJDZJVOS-UHFFFAOYSA-N

Gene Information

human ... ATP4A(495) , ATP4B(496)

Looking for similar products? Visit Product Comparison Guide

Related Categories

Analytical Reference Standards

Sigma-Aldrich

Certified Reference Materials

Chromatography Standards

General description

Omeprazole is a benzimidazole drug, which exhibits antisecretory and antiulcer properties. It is widely used in the treatment of duodenal, gastric ulcers, reflux oesophagitis and against other acid-related diseases.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Omeprazole may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations using spectrophotometric technique and high-performance liquid chromatography technique.

Omeprazole may be used as a reference standard in the determination of omeprazole in pharmaceutical formulations using high performance thin layer chromatography (HPTLC).

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC0716 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

related product

Product No.

Description

Pricing

1478491

1478516

1478561

1478527

PHR1585

Esomeprazole Magnesium, Pharmaceutical Secondary Standard; Certified Reference Material

1478549

Omeprazole magnesium, United States Pharmacopeia (USP) Reference Standard

PHR1648

PHR1649

PHR1650

1478480

1478479

R-Omeprazole, United States Pharmacopeia (USP) Reference Standard

BP765

Omeprazole, British Pharmacopoeia (BP) Reference Standard

PHR1988

Omeprazole Impurity C, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1987

Omeprazole Impurity B, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1989

Omeprazole Impurity H, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1954

N′-Methyl Omeprazole, Pharmaceutical Secondary Standard; Certified Reference Material

Y0002075

Esomeprazole sodium, European Pharmacopoeia (EP) Reference Standard

PHR9054

2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride, certified reference material, TraceCERT^®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

PHR2329

Pictograms

GHS07,GHS09

Signal Word

Warning

Hazard Statements

H302 - H317 - H411

Precautionary Statements

P261 - P264 - P273 - P280 - P301 + P312 - P302 + P352

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

How to Find the Product Number

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503

Product Number

25G

Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

How to Find a Lot/Batch Number for COA

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').
For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').
For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

A validated HPTLC method for determination of ondansetron in combination with omeprazole or rabeprazole in solid dosage form

Raval.B.P, et al.

Indian Journal of Pharmaceutical Sciences, 70(3), 386-386 (2008)

Extractive spectrophotometric determination of omeprazole in pharmaceutical preparations

Bhandage A, et al.

Tropical Journal of Pharmaceutical Research, 8(5), 1133-1142 (2009)

Spectrophotometric determination of omeprazole, lansoprazole and pantoprazole in pharmaceutical formulations

Wahbi AAM, et al.

Journal of Pharmaceutical and Biomedical Analysis, 30(4), 1133-1142 (2002)

A validated normal phase HPLC method for simultaneous determination of drotaverine hydrochloride and omeprazole in pharmaceutical formulation

Topagi SK, et al.

Asian Journal of Pharmaceutical and Clinical Research, 3(1), 20-24 (2010)

Identification of amino acid residues in the ligand-binding domain of the aryl hydrocarbon receptor causing the species-specific response to omeprazole: possible determinants for binding putative endogenous ligands.

Kazuhiro Shiizaki et al.

Molecular pharmacology, 85(2), 279-289 (2013-11-23)

Omeprazole (OME) induces the expression of genes encoding drug-metabolizing enzymes, such as CYP1A1, via activation of the aryl hydrocarbon receptor (AhR) both in vivo and in vitro. However, the precise mechanism of OME-mediated AhR activation is still under investigation. While

View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service