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PHR1080

Supelco

Octinoxate

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):
Octyl methoxycinnamate, OMC, 4-Methoxycinnamic acid 2-ethylhexyl ester, 2-Ethylhexyl 4-methoxycinnamate
Empirical Formula (Hill Notation):
C18H26O3
CAS Number:
Molecular Weight:
290.40
Beilstein:
5946632
EC Number:
MDL number:
PubChem Substance ID:

Quality Level

grade

certified reference material
pharmaceutical secondary standard

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

pharmacopeia traceability

traceable to USP 1477900

storage temp.

2-8°C

SMILES string

CCCCC(CC)COC(=O)\C=C\c1ccc(OC)cc1

InChI

1S/C18H26O3/c1-4-6-7-15(5-2)14-21-18(19)13-10-16-8-11-17(20-3)12-9-16/h8-13,15H,4-7,14H2,1-3H3/b13-10+

InChI key

YBGZDTIWKVFICR-JLHYYAGUSA-N

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Octinoxate belongs to a category of compounds called ‘organic UV-filters (UVFs)′ which constitute an active ingredient of a variety of products, such as cosmetics, sunscreens and lip balms.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Octinoxate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatographic and spectrophotometric techniques.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB3324 in the slot below. This is an example certificate only and may not be the lot that you receive.

Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

379.4 °F

Flash Point(C)

193 °C

Certificate of Analysis

Certificate of Origin

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Dodson RE, et al.
Environmental Health Perspectives, 120(7), 935-943 (2012)
Review of environmental effects of oxybenzone and other sunscreen active ingredients
Schneider SL and Lim HW
Journal of the American Academy of Dermatology, 80(1), 266-271 (2019)
Ozonation of the oxybenzone, octinoxate, and octocrylene UV-filters: Reaction kinetics, absorbance characteristics, and transformation products
Hopkins ZR, et al.
Journal of Hazardous Materials, 338, 23-32 (2017)
Current sunscreen issues: 2007 Food and Drug Administration sunscreen labelling recommendations and combination sunscreen/insect repellent products
Hexsel CL, et al.
Journal of the American Academy of Dermatology, 59(2), 316-323 (2008)
Timothy P Murphy et al.
Journal of the American College of Cardiology, 65(10), 999-1009 (2015-03-15)
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