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PHR1081

Octisalate

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

2-Ethylhexyl salicylate, Octisalate, Octyl salicylate

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About This Item

Linear Formula:
(HO)C6H4CO2CH2CH(C2H5)(CH2)3CH3
CAS Number:
118-60-5
Molecular Weight:
250.33
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823104
EC Number:
204-263-4
Beilstein/REAXYS Number:
2730664
MDL number:
MFCD00053300
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Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to USP 1477943

API family

octisalate

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

refractive index

n20/D 1.502 (lit.)

bp

189-190 °C/21 mmHg (lit.)

density

1.014 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

CCCCC(CC)COC(=O)c1ccccc1O

InChI

1S/C15H22O3/c1-3-5-8-12(4-2)11-18-15(17)13-9-6-7-10-14(13)16/h6-7,9-10,12,16H,3-5,8,11H2,1-2H3

InChI key

FMRHJJZUHUTGKE-UHFFFAOYSA-N

General description

Octisalate is a sunscreen agent that acts as a UV filter for UVB (280-315 nm) radiation.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Octisalate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical and sunscreen formulations by chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC0298 in the slot below. This is an example certificate only and may not be the lot that you receive.

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pictograms

Environment
GHS09

signalword

Warning

hcodes

H410

Hazard Classifications

Aquatic Chronic 1

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

323.6 °F - closed cup

flash_point_c

162 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Thin layer chromatography-spray mass spectrometry: a method for easy identification of synthesis products and UV filters from TLC aluminum foils
Himmelsbach M, et al.
Analytical and Bioanalytical Chemistry, 406(15), 3647-3656 (2014)
Octisalate
USP42-NF37: United States Pharmacopeia and National Formulary
United States Pharmacopeia/National Formulary, 43(3), 3194-3194 (2018)
Development and Validation of RP-HPLC Method for Analysis of Four UV Filters in Sunscreen Products
Yousef AN, et al.
International Journal of Pharmaceutical Sciences Review and Research (2013)
View All Related Papers

Global Trade Item Number

SKUGTIN
PHR1081-10G04061835232888
PHR1081-1G04061837883965