CN
All Photos(1)

PHR1085

Supelco

Homosalate

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):
3,3,5-Trimethylcyclohexyl salicylate, 2-Hydroxybenzoic acid 3,3,5-trimethylcyclohexyl ester, Homomenthyl salicylate, Homosalate
Empirical Formula (Hill Notation):
C16H22O3
CAS Number:
Molecular Weight:
262.34
Beilstein:
2731604
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

Quality Level

grade

certified reference material
pharmaceutical secondary standard

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

cleaning products
cosmetics
environmental
food and beverages
personal care
pharmaceutical (small molecule)

format

neat

pharmacopeia traceability

traceable to USP 1311408

storage temp.

2-30°C

SMILES string

CC1CC(CC(C)(C)C1)OC(=O)c2ccccc2O

InChI

1S/C16H22O3/c1-11-8-12(10-16(2,3)9-11)19-15(18)13-6-4-5-7-14(13)17/h4-7,11-12,17H,8-10H2,1-3H3

InChI key

WSSJONWNBBTCMG-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

General description

Homosalate is a UV filter that protects the skin from the harmful effects of UVB (280-315 nm) and UVA II (315-340 nm) radiations. It is widely utilized in make-up, sunscreen and topical formulations.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Homosalate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography methods.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3174 in the slot below. This is an example certificate only and may not be the lot that you receive.

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

339.4 °F - closed cup

Flash Point(C)

170.8 °C - closed cup

Certificate of Analysis

Certificate of Origin

Supercritical fluid extraction and high performance liquid chromatography determination of homosalate in lipsticks
Salvador A, et al.
Chromatographia, 54(11-12), 795-797 (2001)
Homosalate
USP42-NF37: United States Pharmacopeia and National Formulary
United States Pharmacopeia/National Formulary, 37(2), 2163-2163 (2013)
E Chatelain et al.
Skin pharmacology and applied skin physiology, 16(1), 28-35 (2003-02-05)
To gain information about efficacy and safety of sunscreens, we compared the skin penetration of ultraviolet (UV) filters from two vehicles, i.e. an oil-in-water (O/W) emulsion gel and petrolatum jelly both in vitro and in vivo, as well as the
Comments on "In vitro and in vivo estrogenicity of UV screens".
H M Bolt et al.
Environmental health perspectives, 109(8), A358-A361 (2001-09-21)
Yufeng Zhang et al.
Journal of chromatography. A, 1271(1), 56-61 (2012-12-15)
In the present study, a rapid, highly efficient and environmentally friendly sample preparation method named temperature-controlled ionic liquid dispersive liquid-phase microextraction (TC-IL-DLPME), followed by high performance liquid chromatography (HPLC) was developed for the extraction, preconcentration and determination of four benzophenone-type

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service