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PHR1097

L-Tyrosine

Name: <SC>L</SC>-Tyrosine
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):

(S)-2-Amino-3-(4-hydroxyphenyl)propionic acid, 3-(4-Hydroxyphenyl)-L-alanine

Linear Formula:

4-(HO)C₆H₄CH₂CH(NH₂)CO₂H

CAS Number:

60-18-4

Molecular Weight:

181.19

Beilstein:

392441

EC Number:

200-460-4

MDL number:

MFCD00002606

PubChem Substance ID:

329823119

NACRES:

NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to Ph. Eur. T2900000
traceable to USP 1705006

API family

tyrosine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

>300 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

N[C@@H](Cc1ccc(O)cc1)C(O)=O

InChI

1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1

InChI key

OUYCCCASQSFEME-QMMMGPOBSA-N

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Analytical Reference Standards

Sigma-Aldrich

Certified Reference Materials

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

L-Tyrosine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by a liquid chromatography technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Other Notes

Amino acid precursor of dopamine and other catecholamines

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA7163 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

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High-performance liquid chromatographic analysis of biogenic amines in pharmaceutical products containing Citrus aurantium

Viana C, et al.

Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment, 30(4), 634-642 (2013)

Focal changes in diffusivity on apparent diffusion coefficient MR imaging and amino acid uptake on PET do not colocalize in nonenhancing low-grade gliomas.

Verena Rahm et al.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 55(4), 546-550 (2014-02-26)

Low-grade gliomas (LGGs) may harbor malignant foci, which are characterized by increased tumor cellularity and angiogenesis. We used diffusion-weighted MR imaging (apparent diffusion coefficient [ADC]) and PET with the amino acid O-(2-(18)F-fluorethyl)-L-tyrosine ((18)F-FET) to search for focal changes of diffusion

Mechanism of tyrosine D oxidation in Photosystem II.

Keisuke Saito et al.

Proceedings of the National Academy of Sciences of the United States of America, 110(19), 7690-7695 (2013-04-20)

Using quantum mechanics/molecular mechanics calculations and the 1.9-Å crystal structure of Photosystem II [Umena Y, Kawakami K, Shen J-R, Kamiya N (2011) Nature 473(7345):55-60], we investigated the H-bonding environment of the redox-active tyrosine D (TyrD) and obtained insights that help

Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity.

Hideki Hara et al.

Nature immunology, 14(12), 1247-1255 (2013-11-05)

The inflammasome adaptor ASC contributes to innate immunity through the activation of caspase-1. Here we found that signaling pathways dependent on the kinases Syk and Jnk were required for the activation of caspase-1 via the ASC-dependent inflammasomes NLRP3 and AIM2.

Increased photosystem II stability promotes H2 production in sulfur-deprived Chlamydomonas reinhardtii.

Alena Volgusheva et al.

Proceedings of the National Academy of Sciences of the United States of America, 110(18), 7223-7228 (2013-04-17)

Photobiological H2 production is an attractive option for renewable solar fuels. Sulfur-deprived cells of Chlamydomonas reinhardtii have been shown to produce hydrogen with the highest efficiency among photobiological systems. We have investigated the photosynthetic reactions during sulfur deprivation and H2

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