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PHR1214

Methyl salicylate

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

2-Hydroxybenzoic acid methyl ester, Methyl 2-hydroxybenzoate, Oil of wintergreen, Wintergreen oil

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About This Item

Linear Formula:
2-(HO)C6H4CO2CH3
CAS Number:
119-36-8
Molecular Weight:
152.15
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823221
EC Number:
204-317-7
Beilstein/REAXYS Number:
971516
MDL number:
MFCD00002214

Key Documents

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Product Name

Methyl salicylate, Pharmaceutical Secondary Standard; Certified Reference Material

InChI key

OSWPMRLSEDHDFF-UHFFFAOYSA-N

InChI

1S/C8H8O3/c1-11-8(10)6-4-2-3-5-7(6)9/h2-5,9H,1H3

SMILES string

COC(=O)c1ccccc1O

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to USP 1537450

vapor density

5.26 (vs air)

vapor pressure

1 mmHg ( 54 °C)

API family

methyl salicylate

CofA

current certificate can be downloaded

autoignition temp.

847 °F

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.536 (lit.)

bp

222 °C (lit.)

mp

−8-−7 °C (lit.)

density

1.174 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Quality Level

300

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Analysis Note

These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.

Application

Methyl salicylate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography and voltammetry techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Methyl salicylate is one of the common ingredients present in topical analgesics and rubifacients. It is prescribed for the management of minor muscle aches and pains.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC3556 in the slot below. This is an example certificate only and may not be the lot that you receive.

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Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Dam. 1 - Repr. 2 - Skin Sens. 1B

Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

204.8 °F - closed cup

flash_point_c

96 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Fourier transform mid-infrared (MIR) and near-infrared (NIR) spectroscopy for rapid quality assessment of Chinese medicine preparation Honghua Oil
Wu YW, et al.
Journal of Pharmaceutical and Biomedical Analysis, 46(3), 498-504 (2008)
Optimization and validation of liquid chromatography and headspace-gas chromatography based methods for the quantitative determination of capsaicinoids, salicylic acid, glycol monosalicylate, methyl salicylate, ethyl salicylate, camphor and l-menthol in a topical formulation
Pauwels J, et al.
Journal of Pharmaceutical and Biomedical Analysis, 60(3), 51-58 (2012)
Determination of salicylic acid in pharmaceutical formulations and foods by differential-pulse voltammetry using a glassy carbon electrode
Fung YS and Luk SF
Analyst, 114(8), 943-945 (1989)
Prisca S Pierre et al.
Journal of chemical ecology, 37(4), 368-377 (2011-03-31)
Plants attacked by herbivorous insects emit volatile organic compounds that are used by natural enemies to locate their host or prey. The composition of the blend is often complex and specific. It may vary qualitatively and quantitatively according to plant
Hsu Shao Feng et al.
Journal of clinical periodontology, 38(7), 637-643 (2011-04-01)
To evaluate the clinical efficacy of subgingival ultrasonic instrumentation irrigated with essential oils (EOs) of residual periodontal pockets. Sixty-four individuals with chronic periodontitis were invited to participate in this randomized, double-blind, parallel, and placebo-controlled clinical trial. All subjects received non-surgical
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