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PHR1235

Retinyl Palmitate (Vitamin A Palmitate)

Name: Retinyl Palmitate (Vitamin A Palmitate)
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Retinyl palmitate, Vitamin A palmitate, all−trans−Retinol palmitate

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About This Item

Empirical Formula (Hill Notation):

C₃₆H₆₀O₂

CAS Number:

79-81-2

Molecular Weight:

524.86

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329823240

EC Number:

201-228-5

Beilstein/REAXYS Number:

1917366

MDL number:

MFCD00019414

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Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to USP 1602502

API family

retinyl compounds

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CC1=C(/C=C/C(C)=C/C=C/C(C)=C/COC(CCCCCCCCCCCCCCC)=O)C(C)(C)CCC1

InChI

1S/C36H60O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-25-35(37)38-30-28-32(3)23-20-22-31(2)26-27-34-33(4)24-21-29-36(34,5)6/h20,22-23,26-28H,7-19,21,24-25,29-30H2,1-6H3/b23-20+,27-26+,31-22+,32-28+

InChI key

VYGQUTWHTHXGQB-FFHKNEKCSA-N

Related Categories

Pharmacopeia & Metrological Institute Standards

Analytical Reference Materials for Pharma QC

Certified Reference Materials

Vitamin Standards

General description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards.Retinyl palmitate belongs to a category of compounds called retinoids, which are chemically similar to vitamin A. It exhibits a beneficial effect on vision, skin and immune function, inhibits cell proliferation and prevents cancer. It is an important dietary as well as a therapeutic compound.

Application

Retinyl palmitate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatographic and spectrophotometric techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Review: Vitamin A metabolism.

Analysis Note

These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAC1694 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

GHS08

signalword

Danger

hcodes

H360D,H412

pcodes

P202 - P273 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Aquatic Chronic 3 - Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

No data available

flash_point_c

No data available

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Vitamin A Palmitate-β-cyclodextrin inclusion complexes: Characterization, protection and emulsification properties

Vilanova N and Solans C

Food Chemistry, 175(1-2), 529 -5535 (2015)

Microemulsion electrokinetic chromatography in suppressed electroosmotic flow environment. Separation of fat-soluble vitamins.

S Pedersen-Bjergaard et al.

Journal of chromatography. A, 876(1-2), 201-211 (2000-05-24)

Microemulsion electrokinetic chromatography (MEEKC) was carried out in a pH 2.5 phosphate buffer to effectively suppress the electroosmotic flow (EOF). With 66.6% (w/w) 25 mM phosphate buffer pH 2.5, 20.0% (w/w) 2-propanol, 6.6% (w/w) 1-butanol, 6.0% (w/w) sodium lauryl sulphate

Development of a method for quantitation of retinol and retinyl palmitate in human serum using high-performance liquid chromatography -atmospheric pressure chemical ionization -mass spectrometry

van Breemen RB, et al.

Journal of Chromatography A, 794(1-2), 245-251 (1998)

Embryotoxic doses of vitamin A to rabbits result in low plasma but high embryonic concentrations of all-trans-retinoic acid: risk of vitamin A exposure in humans.

G Tzimas et al.

The Journal of nutrition, 126(9), 2159-2171 (1996-09-01)

Retinoid pharmacokinetics were examined in plasma, placenta and embryos of gestational d 12 rabbits following application of an embryotoxic dosing regimen (10 mg retinyl palmitate/kg body wt per day from gestational d 7 to 12). Vehicle-treated or untreated rabbits served

Different postprandial metabolism of olive oil and soybean oil: a possible mechanism of the high-density lipoprotein conserving effect of olive oil.

T W de Bruin et al.

The American journal of clinical nutrition, 58(4), 477-483 (1993-10-01)

The postprandial lipoprotein metabolism of two orally administered vitamin A-fat loads consisting of either 20% (wt:vol) soybean oil or 17% olive oil plus 3% soybean oil was studied in six normolipidemic young men according to a randomized crossover design. Mean

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Global Trade Item Number

SKU	GTIN
PHR1235-1G	04061837884054

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