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PHR1239

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β-Carotene

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
β,β-Carotene, Provitamin A
Empirical Formula (Hill Notation):
C40H56
CAS Number:
7235-40-7
Molecular Weight:
536.87
Beilstein:
1917416
EC Number:
230-636-6
MDL number:
MFCD00001556
PubChem Substance ID:
329823244
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to USP 1065480

API family

carotenes

form

solid

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

food and beverages

format

neat

storage temp.

-10 to -25°C

SMILES string

CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C2=C(C)CCCC2(C)C)C(C)(C)CCC1

InChI

1S/C40H56/c1-31(19-13-21-33(3)25-27-37-35(5)23-15-29-39(37,7)8)17-11-12-18-32(2)20-14-22-34(4)26-28-38-36(6)24-16-30-40(38,9)10/h11-14,17-22,25-28H,15-16,23-24,29-30H2,1-10H3/b12-11+,19-13+,20-14+,27-25+,28-26+,31-17+,32-18+,33-21+,34-22+

InChI key

OENHQHLEOONYIE-JLTXGRSLSA-N

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
β-Carotene is an antioxidant and is one of the most important carotenoids and a source of vitamin A. It is abundantly present in fruits and vegetables which is also used as a food supplement and a colorant.

Application

β-Carotene may be used as a pharmaceutical reference standard for the determination of the analyte in serum, plasma samples, fruits and vegetables by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

The most important of the provitamins A, β-carotene can be classified as an antioxidant due to its inhibition of radical initiated peroxidation in vitro. However, in vivo it appears to act either as an antioxidant or a prooxidant depending on cellular environment. It reduces the incidence of many cancers, but enhances lung cancer incidence in smokers.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC0284 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

217.9 °F - closed cup

Flash Point(C)

103.3 °C - closed cup

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Simultaneous determination of retinol, alpha-tocopherol and beta-carotene in serum by isocratic high-performance liquid chromatography
Arnaud J, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 572(1-2), 103-116 (1991)
Angélica M Jaramillo et al.
PloS one, 13(12), e0209702-e0209702 (2018-12-29)
The most commonly used method for measuring carotenoid concentration is high-performance liquid chromatography (HPLC). Nevertheless, easier, quicker, and less costly proxy methods exist. We aimed to determine the diagnostic performance of several proxy methods: the spectrophotometer, iCheck Carotene, and near-infrared
Determination of alpha and beta-Carotene in Fruit and Vegetables by High Performance Liquid Chromatography
Wilson AM, et al.
Can. Inst. Food Sci Technol. J., 15(3), 165-169 (1982)
High-performance liquid chromatographic method for routine determination of vitamins A and E and beta-carotene in plasma
Lee BL, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 581(1), 41-47 (1992)
Beta-carotene and the application of transcriptomics in risk--benefit evaluation of natural dietary components
Keijer J, et al.
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1740(2), 139-146 (2005)
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Protocols

HPLC Analysis of Carotene Compounds on Ascentis® RP-Amide

HPLC Analysis of Carotene Compounds on Ascentis® RP-Amide

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