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PHR1241

L-Methionine

Name: <SC>L</SC>-Methionine
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):

(S)-2-Amino-4-(methylmercapto)butyric acid, L-2-Amino-4-(methylthio)butanoic acid

Linear Formula:

CH₃SCH₂CH₂CH(NH₂)CO₂H

CAS Number:

63-68-3

Molecular Weight:

149.21

Beilstein:

1722294

EC Number:

200-562-9

MDL number:

MFCD00063097

PubChem Substance ID:

329823245

NACRES:

NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to Ph. Eur. M0960000
traceable to USP 1411504

API family

methionine & derivatives

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

284 °C (dec.) (lit.)

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care
pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

CSCC[C@H](N)C(O)=O

InChI

1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1

InChI key

FFEARJCKVFRZRR-BYPYZUCNSA-N

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Related Categories

Analytical Reference Standards

Sigma-Aldrich

Certified Reference Materials

Food & Cosmetic Component Standards

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

L-Methionine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by ion chromatography.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA9045 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

related product

Product No.

Description

Pricing

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Ion-chromatographic determination of carbocisteine in pharmaceuticals based on non-suppressed conductimetric detection

Megoulas NC and Koupparis MA

Journal of Chromatography A, 1026(1-2), 167-174 (2004)

Analysis of metabolic profiles of bile acids in urine using a lipophilic anion exchanger and computerized gas-liquid chromatorgaphy-mass spectrometry.

B Almé et al.

Journal of lipid research, 18(3), 339-362 (1977-05-01)

A method is described for quantitative analysis of bile acids in urine. Urine is acidified and bile acids are extracted on an Amberlite XAD-2 column. Bile salts are converted to acids on an Amberlyst A-15 column and are separated into

Value of 11C-methionine PET in imaging brain tumours and metastases.

Andor W J M Glaudemans et al.

European journal of nuclear medicine and molecular imaging, 40(4), 615-635 (2012-12-13)

(11)C-methionine (MET) is the most popular amino acid tracer used in PET imaging of brain tumours. Because of its characteristics, MET PET provides a high detection rate of brain tumours and good lesion delineation. This review focuses on the role

Correction of the consequences of mitochondrial 3243A>G mutation in the MT-TL1 gene causing the MELAS syndrome by tRNA import into mitochondria.

Olga Z Karicheva et al.

Nucleic acids research, 39(18), 8173-8186 (2011-07-05)

Mutations in human mitochondrial DNA are often associated with incurable human neuromuscular diseases. Among these mutations, an important number have been identified in tRNA genes, including 29 in the gene MT-TL1 coding for the tRNA(Leu(UUR)). The m.3243A>G mutation was described

Planar scintigraphy with 123I/99mTc-sestamibi, 99mTc-sestamibi SPECT/CT, 11C-methionine PET/CT, or selective venous sampling before reoperation of primary hyperparathyroidism?

Camilla Schalin-Jäntti et al.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 54(5), 739-747 (2013-04-05)

All patients with primary hyperparathyroidism should undergo localization studies before reoperation, but it is not known which method is most accurate. The purpose of this prospective study was to compare the performance of planar scintigraphy with (123)I/(99m)Tc-sestamibi, (99m)Tc-sestamibi SPECT (SPECT/CT)

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Articles

USP HPLC Analysis of L-Methionine on Ascentis® Express OH5

Separation of L-Methionine, Pharmaceutical Secondary Standard; Certified Reference Material

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