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PHR1254

Supelco

Acyclovir

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):
9-[(2-Hydroxyethoxy)methyl]guanine, Acyclovir, Acycloguanosine
Empirical Formula (Hill Notation):
C8H11N5O3
CAS Number:
Molecular Weight:
225.20
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

Quality Level

grade

certified reference material
pharmaceutical secondary standard

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

pharmacopeia traceability

traceable to BP 438
traceable to PhEur A0220000
traceable to USP 1012065

storage temp.

2-30°C

SMILES string

NC1=Nc2c(ncn2COCCO)C(=O)N1

InChI

1S/C8H11N5O3/c9-8-11-6-5(7(15)12-8)10-3-13(6)4-16-2-1-14/h3,14H,1-2,4H2,(H3,9,11,12,15)

InChI key

MKUXAQIIEYXACX-UHFFFAOYSA-N

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Acyclovir is an acyclic guanosine derivative effective in the treatment of skin infections caused by herpes simplex virus.

Application

Acyclovir may be used as a pharmaceutical reference standard for the determination of the analyte in plasma, serum samples and bulk drug/formulations by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC2956 in the slot below. This is an example certificate only and may not be the lot that you receive.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Determination of acyclovir in human serum by high-performance liquid chromatography using liquid--liquid extraction and its application in pharmacokinetic studies
Bahrami Gh, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 816(1-2), 327-331 (2005)
Simple spectrophotometric determination of acyclovir in bulk drug and formulations
Basavaiah K and Prameela HC
Il Farmaco (Societa Chimica Italiana : 1989), 57(6), 443-449 (2002)
Determination of acyclovir in human plasma by high-performance liquid chromatography
Boulieu R, et al
Journal of Chromatography. B, Biomedical Sciences and Applications, 693(1), 233-236 (1997)
Swetha G Pinninti et al.
Pediatric clinics of North America, 60(2), 351-365 (2013-03-14)
Neonatal herpes simplex virus infections are uncommon, but because of the morbidity and mortality associated with the infection they are often considered in the differential diagnosis of ill neonates. The use of polymerase chain reaction for diagnosis of central nervous
Monique van Velzen et al.
The Journal of infectious diseases, 208(9), 1359-1365 (2013-08-01)
Long-term acyclovir (ACV) prophylaxis, recommended to prevent recurrent herpes simplex virus type 1 (HSV-1) ocular disorders, may pose a risk for ACV-refractory disease due to ACV resistance. We determined the effect of ACV prophylaxis on the prevalence of corneal ACV-resistant

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