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COO/COA

PHR1256

Abacavir sulfate

Name: Abacavir sulfate
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):

Abacavir sulfate, {(1S, 4R)-4-[2-Amino-6- (cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol}

Empirical Formula (Hill Notation):

C₂₈H₃₆N₁₂O₂ · H₂SO₄

CAS Number:

188062-50-2

Molecular Weight:

670.74

NACRES:

NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to Ph. Eur. Y0001561
traceable to USP 1000408

API family

abacavir

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

InChI

1S/2C14H18N6O.H2O4S/c2*15-14-18-12(17-9-2-3-9)11-13(19-14)20(7-16-11)10-4-1-8(5-10)6-21;1-5(2,3)4/h2*1,4,7-10,21H,2-3,5-6H2,(H3,15,17,18,19);(H2,1,2,3,4)/t2*8-,10+;/m11./s1

InChI key

WMHSRBZIJNQHKT-FFKFEZPRSA-N

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Related Categories

Analytical Reference Standards

Sigma-Aldrich

Certified Reference Materials

General description

Abacavir sulfate belongs to the class of human immunodeficiency virus (HIV) medicines called nucleoside reverse transcriptase inhibitors, with antiretroviral activity against HIV.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Abacavir sulfate may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using high-peformance liquid chromatography technique and spectrophotometric technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3642 in the slot below. This is an example certificate only and may not be the lot that you receive.

related product

Product No.

Description

Pricing

1000485

1000420

1000441

1000452

Y0001561

Abacavir sulfate, European Pharmacopoeia (EP) Reference Standard

Y0001551

Abacavir for system suitability, European Pharmacopoeia (EP) Reference Standard

Y0001552

Abacavir for peak identification, European Pharmacopoeia (EP) Reference Standard

1000437

BP1112

Abacavir sulfate, British Pharmacopoeia (BP) Reference Standard

BP1113

Abacavir impurity standard, British Pharmacopoeia (BP) Reference Standard

BP1114

Abacavir Impurity 1, British Pharmacopoeia (BP) Reference Standard

PHR2064

PHR2074

Abacavir Impurity F, pharmaceutical secondary standard, certified reference material

Pictograms

GHS07,GHS08

Signal Word

Warning

Hazard Statements

H317 - H319 - H341 - H351 - H361

Precautionary Statements

P202 - P261 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313

Hazard Classifications

Carc. 2 - Eye Irrit. 2 - Muta. 2 - Repr. 2 - Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Determination of abacavir, lamivudine and zidovudine in pharmaceutical tablets, human serum and in drug dissolution studies by HPLC

Savaser A, et al.

Chromatographia, 65(5-6), 259-265 (2007)

Spectrophotometric methods for the determination of abacavir sulphate in pharmaceutical preparations

Srihari G

Global Journal of Pharmacology, 5(3), 172-175 (2011)

Articles

LC-MS Analysis of Serum for a Wide Analyte Range Using a Novel HLB SPE Phase

Analysis of 20 pharmaceutical compounds in calf serum using Supel™ Swift HLB SPE cartridge for cleanup and LC-MS determination and another commercially available HLB cartridge for comparison.

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