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PHR1269

Eugenol

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

2-Methoxy-4-(2-propenyl)phenol, 4-Allyl-2-methoxyphenol, 4-Allylguaiacol

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About This Item

Linear Formula:
4-(H2C=CHCH2)C6H3-2-(OCH3)OH
CAS Number:
97-53-0
Molecular Weight:
164.20
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823265
EC Number:
202-589-1
Beilstein/REAXYS Number:
1366759
MDL number:
MFCD00008654

Key Documents

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Product Name

Eugenol, Pharmaceutical Secondary Standard; Certified Reference Material

InChI key

RRAFCDWBNXTKKO-UHFFFAOYSA-N

InChI

1S/C10H12O2/c1-3-4-8-5-6-9(11)10(7-8)12-2/h3,5-7,11H,1,4H2,2H3

SMILES string

COc1cc(CC=C)ccc1O

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. E5000000
traceable to USP 1268965

API family

eugenol

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.541 (lit.)

bp

254 °C (lit.)

mp

−12-−10 °C (lit.)

density

1.067 g/mL at 25 °C (lit.)

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care
pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Quality Level

300

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Analysis Note

These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.

Application

Eugenol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA0005 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H317,H319

Hazard Classifications

Eye Irrit. 2 - Skin Sens. 1

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

255.2 °F - closed cup

flash_point_c

124 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Static headspace gas chromatography of (semi-) volatile drugs in pharmaceuticals for topical use.
Sitaramaraju Y, et al.
Journal of Pharmaceutical and Biomedical Analysis, 47(4-5), 834-840 (2008)
Validated RP-HPLC method to estimate eugenol from commercial formulations like Caturjata Churna, Lavangadi Vati, Jatiphaladi Churna, Sitopaladi Churna and clove oil.
Saran S, et al.
Journal of Pharmacy Research, 6(1), 53-60 (2013)
Quantitative HPTLC analysis of the eugenol content of leaf powder and a capsule formulation of Ocimum sanctum.
Lalla J, et al.
JPC-Journal of Planar Chromatography-Modern TLC, 20(2), 135-138 (2007)
Warayuth Sajomsang et al.
Carbohydrate polymers, 92(1), 321-327 (2012-12-12)
In this study two types of water-soluble βCD grafted chitosan were synthesized and compared based on similar degree of N-substitution of βCD moiety; QCD23-g-CS contained methylene spacer and QCDCA22-g-CS contained citric acid spacer. The QCD23-g-CS demonstrated greater eugenol (EG) encapsulation
I U Fischer et al.
Journal of chromatography, 525(2), 369-377 (1990-02-23)
The high-performance liquid chromatographic assay described permitted a simple, rapid, sensitive, selective and precise quantitative determination of eugenol in body fluids (serum, urine and bile) without derivatization. Amounts in the range 0.02-100 micrograms of eugenol per millilitre of body fluid
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