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PHR1276

Niacin (Nicotinic Acid)

Name: Niacin (Nicotinic Acid)
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):

Nicotinic acid, 3-Picolinic acid, Niacin, Pellagra preventive factor, Pyridine-3-carboxylic acid, Vitamin B₃

Empirical Formula (Hill Notation):

C₆H₅NO₂

CAS Number:

59-67-6

Molecular Weight:

123.11

Beilstein:

109591

EC Number:

200-441-0

MDL number:

MFCD00006391

PubChem Substance ID:

329823272

NACRES:

NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to Ph. Eur. N0700000
traceable to USP 1461003

API family

nicotinic acid

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

236-239 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

OC(=O)c1cccnc1

InChI

1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)

InChI key

PVNIIMVLHYAWGP-UHFFFAOYSA-N

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Related Categories

Analytical Reference Standards

Certified Reference Materials

Pharmacopeia & Metrological Institute Standards

Vitamin Standards

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Niacin (Nicotinic Acid) is commonly used as a dietary supplement, and its deficiency can cause pellagra. It is involved in the synthesis of coenzymes such as NAD and NADP, which are quite essential for enzymatic reactions.
As a lipid-lowering agent, it helps in the prevention of coronary heart disease, carotid artery disease and other atherosclerotic vascular diseases.

Application

Niacin (Nicotinic Acid) may be used as a secondary pharma standard for the quantification of the analyte in pharmaceutical formulations using spectrophotometric technique and reversed-phase high-performance liquid chromatography technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB7604 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

related product

Product No.

Description

Pricing

Signal Word

Warning

Hazard Statements

H319

Precautionary Statements

P280 - P305 + P351 + P338 - P337 + P313

Hazard Classifications

Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

379.4 °F - closed cup

Flash Point(C)

193 °C - closed cup

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Development and Validation of RP-HPLC Method for the Estimation of Rosuvastatin Calcium and Niacin in Combined Tablet Dosage Form

MSN, et al.

International Journal of Pharma Research & Review, 4(6), 44-50 (2015)

Simultaneous determination of lovastatin and niacin in tablet by first and third derivative spectrophotometry and H-point standard addition methods

Kazemipour M, et al.

Research in Pharmaceutical Sciences, 7(2), 95-95 (2012)

The Vitamin Cure: Clinically Proven Remedies to Prevent and Treat 75 Chronic Diseases and Conditions (2018)

Stabilities of dobutamine, dopamine, nitroglycerin and sodium nitroprusside in disposable plastic syringes.

Journal of Clinical Pharmacy and Therapeutics null

Metabolomics Studies to Assess Biological Functions of Vitamin E Nicotinate.

Lucia Marcocci et al.

Antioxidants (Basel, Switzerland), 8(5) (2019-05-15)

Vitamin E nicotinate (tocopherol nicotinate, tocopheryl nicotinate; TN) is an ester of two vitamins, tocopherol (vitamin E) and niacin (vitamin B3), in which niacin is linked to the hydroxyl group of active vitamin E. This vitamin E ester can be

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