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PHR1301

Ensulizole(2-Phenylbenzimidazole 5-sulfonic acid)

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

2-Phenyl-5-benzimidazolesulfonic acid, Ensulizole

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About This Item

Empirical Formula (Hill Notation):
C13H10N2O3S
CAS Number:
27503-81-7
Molecular Weight:
274.30
NACRES:
NA.24
PubChem Substance ID:
329823289
UNSPSC Code:
41116107
MDL number:
MFCD00053007
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Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to USP 1530809

API family

ensulizole

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

>300 °C (lit.)

application(s)

environmental
pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

OS(=O)(=O)c1ccc2[nH]c(nc2c1)-c3ccccc3

InChI

1S/C13H10N2O3S/c16-19(17,18)10-6-7-11-12(8-10)15-13(14-11)9-4-2-1-3-5-9/h1-8H,(H,14,15)(H,16,17,18)

InChI key

UVCJGUGAGLDPAA-UHFFFAOYSA-N

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Ensulizole(2-Phenylbenzimidazole 5-sulfonic acid) may be used as a pharmaceutical reference standard for the determination of the analyte in sunscreen formulations by high performance liquid chromatography (HPLC) technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC0273 in the slot below. This is an example certificate only and may not be the lot that you receive.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ashley R Heurung et al.
Dermatitis : contact, atopic, occupational, drug, 25(6), 289-326 (2014-11-11)
Sunscreen is a key component in the preventive measures recommended by dermatologists and public health campaigns aimed at reducing sunburn, early skin aging, and skin cancer. To maximize compliance, adverse reactions to sunscreens should be minimized. Although inactive ingredients cause
J Shokri et al.
Drug research, 63(11), 591-596 (2013-07-12)
There is a serious concern about the topical and systemic absorption of organic ultraviolet filters in sunscreen formulations and subsequent phototoxic and photo allergic reactions. Ideally, a sunscreen should localize in the surface of stratum corneum and create a barrier

Global Trade Item Number

SKUGTIN
PHR1301-1G04061834415794