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PHR1308

Propranolol hydrochloride

Name: Propranolol hydrochloride
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

(±)-Propranolol hydrochloride, (±)-1-Isopropylamino-3-(1-naphthyloxy)-2-propanol hydrochloride, DL-Propranolol hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₂₁NO₂ · HCl

CAS Number:

318-98-9

Molecular Weight:

295.80

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329823295

EC Number:

206-268-7

Beilstein/REAXYS Number:

4164259

MDL number:

MFCD00012558

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Properties

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. P3500000, traceable to USP 1576005

API family

propranolol

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

Cl.CC(C)NCC(O)COc1cccc2ccccc12

InChI

1S/C16H21NO2.ClH/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16;/h3-9,12,14,17-18H,10-11H2,1-2H3;1H

InChI key

ZMRUPTIKESYGQW-UHFFFAOYSA-N

Gene Information

human ... ADRB1(153), ADRB2(154)

Description

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Propranolol is a β-adrenergic blocking compound, widely used for the management of cardiac arrhythmia, sinus tachycardia, angina pectoris and hypertension. It is also prescribed for the treatment of dysfunctional labor, migraine, as well as anxiety.

Application

Propranolol hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and plasma samples by chromatography and spectrophotometry.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAA0068 in the slot below. This is an example certificate only and may not be the lot that you receive.

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pictograms

GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

监管及禁止进口产品

This item has

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Micellar liquid chromatographic determination of five antianginals in pharmaceuticals

Gil-Agusti M, et al.

Journal of Pharmaceutical and Biomedical Analysis, 41(4), 1235-1242 (2006)

High-pressure liquid chromatographic method for the simultaneous quantitative analysis of propranolol and 4-hydroxypropranolol in plasma

Nation RI, et al.

Journal of Chromatography. B, Biomedical Sciences and Applications, 145(3), 429-436 (1978)

AAS and spectrophotometric determination of propranolol HCl and metoprolol tartrate

El-Ries MA, et al.

Journal of Pharmaceutical and Biomedical Analysis, 24(2), 179-187 (2000)

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Global Trade Item Number

SKU	GTIN
PHR1308-1G	04061835233588