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Benzene

Pharmaceutical Secondary Standard; Certified Reference Material

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Empirical Formula (Hill Notation):
C6H6
CAS Number:
71-43-2
Molecular Weight:
78.11
Beilstein:
969212
EC Number:
200-753-7
MDL number:
MFCD00003009
PubChem Substance ID:
329823296
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to NIST 3000
traceable to USP 1601146

vapor density

2.77 (vs air)

vapor pressure

166 mmHg ( 37.7 °C)
74.6 mmHg ( 20 °C)

CofA

current certificate can be downloaded

autoignition temp.

1043 °F

expl. lim.

8 %

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.501 (lit.)

bp

80 °C (lit.)

mp

5.5 °C (lit.)

density

0.874 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

c1ccccc1

InChI

1S/C6H6/c1-2-4-6-5-3-1/h1-6H

InChI key

UHOVQNZJYSORNB-UHFFFAOYSA-N

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards..

Application

Benzene may be used as a pharmaceutical reference standard for the determination of benzene residues in pharmaceutical products by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3166 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Signal Word

Danger

Hazard Classifications

Aquatic Chronic 3 - Asp. Tox. 1 - Carc. 1A - Eye Irrit. 2 - Flam. Liq. 2 - Muta. 1B - Skin Irrit. 2 - STOT RE 1

Target Organs

Blood

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

12.2 °F

Flash Point(C)

-11 °C

Regulatory Information

危险化学品

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Factors that influence the determination of residual solvents in pharmaceuticals by automated static headspace sampling coupled to capillary GC-MS.
Mulligan KJ and McCauley H
Journal of Chromatographic Science, 33(1), 49-54 (1995)
A general static-headspace gas chromatographic method for determination of residual benzene in oral liquid pharmaceutical products.
Liu H, et al.
Journal of Pharmaceutical and Biomedical Analysis, 54(2), 417-421 (2011)
Matrix media selection for the determination of residual solvents in pharmaceuticals by static headspace gas chromatography.
Urakami K, et al.
Journal of Chromatography A, 1057(1-2), 203-210 (2004)
Jelle Vlaanderen et al.
Environmental health perspectives, 119(2), 159-167 (2010-10-01)
The use of occupational cohort studies to assess the association of benzene and lymphoma is complicated by problems with exposure misclassification, outcome classification, and low statistical power. We performed meta-analyses of occupational cohort studies for five different lymphoma categories: Hodgkin
Cliona M McHale et al.
Carcinogenesis, 33(2), 240-252 (2011-12-15)
Benzene causes acute myeloid leukemia and probably other hematological malignancies. As benzene also causes hematotoxicity even in workers exposed to levels below the US permissible occupational exposure limit of 1 part per million, further assessment of the health risks associated
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