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PHR1336

Nimesulide

Name: Nimesulide
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Nimesulide, N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide

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About This Item

Empirical Formula (Hill Notation):

C₁₃H₁₂N₂O₅S

CAS Number:

51803-78-2

Molecular Weight:

308.31

NACRES:

NA.24

PubChem Substance ID:

329823321

UNSPSC Code:

41116107

EC Number:

257-431-4

MDL number:

MFCD00079470

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Properties

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. N0845000

API family

nimesulide

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

CS(NC1=C(OC2=CC=CC=C2)C=C([N+]([O-])=O)C=C1)(=O)=O

InChI

1S/C13H12N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h2-9,14H,1H3

InChI key

HYWYRSMBCFDLJT-UHFFFAOYSA-N

Description

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Nimesulide is a selective cyclooxygenase-2 (COX-2) inhibitor that can potentially be used as a therapeutic agent for the treatment of inflammatory conditions. It is also a non-steroidal anti-inflammatory drug (NSAID) that possesses analgesic and antipyretic characters.

Application

Nimesulide may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometry and chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Highly selective cyclooxygenase-2 inhibitor.

Analysis Note

These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAA1070 in the slot below. This is an example certificate only and may not be the lot that you receive.

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pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P301 + P310

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Determination of nimesulide in pharmaceutical dosage forms by second order derivative UV spectrophotometry

Altinoz S and Dursun OO

Journal of Pharmaceutical and Biomedical Analysis, 22(1), 175-182 (2000)

Improved high-performance liquid chromatographic assay for nimesulide

Jaworowicz Jr DJ, et al.

Journal of Chromatography. B, Biomedical Sciences and Applications, 723(1-2), 293-299 (1999)

Validated HPTLC method for nimesulide and dicyclomine hydrochloride in formulation

Dhaneshwar SR, et al.

Journal of Pharmacy Research, 4(7), 2288-2290 (2011)

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Global Trade Item Number

SKU	GTIN
PHR1336-1G	04061835233687