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PHR1375

Ketoprofen

Name: Ketoprofen
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):

Ketoprofen, KP, 2-(3-Benzoylphenyl)propionic acid

Empirical Formula (Hill Notation):

C₁₆H₁₄O₃

CAS Number:

22071-15-4

Molecular Weight:

254.28

EC Number:

244-759-8

MDL number:

MFCD00055790

PubChem Substance ID:

329823352

NACRES:

NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to BP 668
traceable to Ph. Eur. K2000000
traceable to USP 1356632

API family

ketoprofen

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

CC(C(O)=O)c1cccc(c1)C(=O)c2ccccc2

InChI

1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)

InChI key

DKYWVDODHFEZIM-UHFFFAOYSA-N

Gene Information

human ... PTGS1(5742) , PTGS2(5743)

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Related Categories

Analytical Reference Standards

Certified Reference Materials

Chromatography Standards

Pharmacopeia & Metrological Institute Standards

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Ketoprofen is an active pharmaceutical compound used as a non-steroidal anti-inflammatory drug (NSAID). It is essentially a non-narcotic drug extensively utilized for mild to moderate pain relief.

Application

Ketoprofen may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography and spectrophotometric technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Non-steroidal anti-inflammatory compound that is selective for COX-1.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3470 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

related product

Product No.

Description

Pricing

1356643

1356563

1356552

BP668

Ketoprofen, British Pharmacopoeia (BP) Reference Standard

BP667

Ketoprofen ethyl ester, British Pharmacopoeia (BP) Reference Standard

PHR2877

PHR2955

PHR3018

Pictograms

GHS06

Signal Word

Danger

Hazard Statements

H301

Precautionary Statements

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

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Development and validation of a stability-indicating high-performance liquid chromatographic assay for ketoprofen topical penetrating gel

Bempong DK and Bhattacharyya L

Journal of Chromatography A, 1073(1-2), 341-346 (2005)

Simultaneous HPLC determination of ketoprofen and its degradation products in the presence of preservatives in pharmaceuticals

Dvorak J, et al.

Journal of Pharmaceutical and Biomedical Analysis, 36(3), 625-629 (2004)

UV-spectrophotometric determination of ketoprofen and paraben in a gel preparation by partial least-squares calibration

Blanco M, et al.

Fresenius Journal of Analytical Chemistry, 357(7), 967-972 (1997)

Photosensitivity to ketoprofen: mechanisms and pharmacoepidemiological data.

H Bagheri et al.

Drug safety, 22(5), 339-349 (2000-06-01)

The topical use of nonsteroidal anti-inflammatory drugs (NSAIDs), widely used for moderate acute and chronic painful conditions, is one of several strategies used to improve the tolerability profile of NSAIDs, particularly with regard to gastric and renal adverse effects. However

Biowaiver monographs for immediate-release solid oral dosage forms: ketoprofen.

Igor E Shohin et al.

Journal of pharmaceutical sciences, 101(10), 3593-3603 (2012-07-13)

Literature and experimental data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate-release (IR) solid oral dosage forms containing ketoprofen are reviewed. Ketoprofen's solubility and permeability, its therapeutic use and

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