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PHR1389

Propyphenazone

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

4-Isopropylantipyrine, 1,2-Dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl-3H-pyrazol-3-one, 1,2-Dihydro-4-isopropyl-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one, Isopropylphenazone, Propyphenazone

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About This Item

Empirical Formula (Hill Notation):
C14H18N2O
CAS Number:
479-92-5
Molecular Weight:
230.31
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823364
MDL number:
MFCD00053368
Beilstein/REAXYS Number:
204533

Key Documents

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Product Name

Propyphenazone, Pharmaceutical Secondary Standard; Certified Reference Material

InChI

1S/C14H18N2O/c1-10(2)13-11(3)15(4)16(14(13)17)12-8-6-5-7-9-12/h5-10H,1-4H3

SMILES string

O=C1C(C(C)C)=C(C)N(C)N1C2=CC=CC=C2

InChI key

PXWLVJLKJGVOKE-UHFFFAOYSA-N

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. P3750000

API family

propyphenazone 

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Quality Level

300

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Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Application

Propyphenazone can be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatographic and spectrophotometric techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Propyphenazone is a nonsteroidal drug exhibiting anti-inflammatory properties. It is widely used as a mild anesthetic medicine. It belongs to the pyrazolone class of compounds and has been posited to elicit an allergic or pseudo allergic reaction.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA1896 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Simultaneous determination of paracetamol, caffeine and propyphenazone in ternary mixtures by micellar electrokinetic capillary chromatography
Emre D and Ozalt?n, Nuran
Journal of Chromatography. B, Biomedical Sciences and Applications, 847(2), 126-132 (2007)
A rapid spectrophotometric method to resolve ternary mixtures of propyphenazone, caffeine, and acetaminophen in tablets
Ozgur MU, et al.
Monatshefte fur Chemie / Chemical Monthly, 133(2), 219-223 (2002)
High-performance Liquid Chromatographic Determination of Paracetamol, Propyphenazone, and Caffeine in Pharmaceutical Formulations
Delvadiya K, et al.
Indian Journal of Pharmaceutical Education and Research, 47(4), 65-72 (2014)
Derivative ratio spectra-zero crossing spectrophotometry and LC method applied to the quantitative determination of paracetamol, propyphenazone and caffeine in ternary mixtures
Dinc E, et al.
Journal of Pharmaceutical and Biomedical Analysis, 26(5-6), 769-778 (2001)
Ngoc Han Tran et al.
Journal of hazardous materials, 171(1-3), 1051-1057 (2009-07-21)
The biodegradation of 10 selected pharmaceuticals by enriched nitrifier cultures with ammonia oxidizing activity of 30mg NH(4)-N/gMLVSSh was investigated under various initial operating conditions such as in the presence of different growth substrates and inhibitors. The enriched nitrifier culture showed
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