PHR1389
异丙安替比林
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
4-Isopropylantipyrine, 1,2-Dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl-3H-pyrazol-3-one, 1,2-Dihydro-4-isopropyl-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one, Isopropylphenazone, Propyphenazone
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关于此项目
经验公式（希尔记法）:
C14H18N2O
化学文摘社编号:
分子量:
230.31
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
204533
产品名称
异丙安替比林, Pharmaceutical Secondary Standard; Certified Reference Material
InChI
1S/C14H18N2O/c1-10(2)13-11(3)15(4)16(14(13)17)12-8-6-5-7-9-12/h5-10H,1-4H3
SMILES string
O=C1C(C(C)C)=C(C)N(C)N1C2=CC=CC=C2
InChI key
PXWLVJLKJGVOKE-UHFFFAOYSA-N
grade
certified reference material
pharmaceutical secondary standard
agency
traceable to Ph. Eur. P3750000
API family
propyphenazone
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
Quality Level
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Analysis Note
These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.
Application
Propyphenazone can be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatographic and spectrophotometric techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
General description
Propyphenazone is a nonsteroidal drug exhibiting anti-inflammatory properties. It is widely used as a mild anesthetic medicine. It belongs to the pyrazolone class of compounds and has been posited to elicit an allergic or pseudo allergic reaction.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Other Notes
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA1896 in the slot below. This is an example certificate only and may not be the lot that you receive.
A rapid spectrophotometric method to resolve ternary mixtures of propyphenazone, caffeine, and acetaminophen in tablets
Ozgur MU, et al.
Monatshefte fur Chemie / Chemical Monthly, 133(2), 219-223 (2002)
High-performance Liquid Chromatographic Determination of Paracetamol, Propyphenazone, and Caffeine in Pharmaceutical Formulations
Delvadiya K, et al.
Indian Journal of Pharmaceutical Education and Research, 47(4), 65-72 (2014)
Simultaneous determination of paracetamol, caffeine and propyphenazone in ternary mixtures by micellar electrokinetic capillary chromatography
Emre D and Ozalt?n, Nuran
Journal of Chromatography. B, Biomedical Sciences and Applications, 847(2), 126-132 (2007)
Derivative ratio spectra-zero crossing spectrophotometry and LC method applied to the quantitative determination of paracetamol, propyphenazone and caffeine in ternary mixtures
Dinc E, et al.
Journal of Pharmaceutical and Biomedical Analysis, 26(5-6), 769-778 (2001)
Traugott J Scheytt et al.
Journal of contaminant hydrology, 83(1-2), 53-69 (2005-12-14)
Many pharmaceuticals pass the unsaturated zone before reaching an aquifer. Therefore, laboratory sand column transport experiments were conducted to study the transport behavior of carbamazepine, diclofenac, ibuprofen, and propyphenazone under unsaturated conditions. The test water was artificial sewage effluent to
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