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PHR1418

Supelco

Succinic Acid

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):
Butanedioic acid, Succinic acid
Linear Formula:
HOOCCH2CH2COOH
CAS Number:
Molecular Weight:
118.09
Beilstein:
1754069
EC Number:
MDL number:
PubChem Substance ID:

Quality Level

grade

certified reference material
pharmaceutical secondary standard

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

bp

235 °C (lit.)

mp

184-186 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

pharmacopeia traceability

traceable to USP 1623411

storage temp.

2-30°C

SMILES string

OC(=O)CCC(O)=O

InChI

1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)

InChI key

KDYFGRWQOYBRFD-UHFFFAOYSA-N

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General description

Succinic acid is a dicarboxylic acid, which is used primarily as an acidity regulator in the food and beverage industry. Pharmaceutically, it is usually used as a conjugate feeder acid to form succinate salt and as an excipient.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Succinic acid may be used as a pharmaceutical reference standard for the determination of the analyte in raw material, food and pharmaceutical formulations by high performance liquid chromatography.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC2952 in the slot below. This is an example certificate only and may not be the lot that you receive.

Pictograms

Corrosion

Signal Word

Danger

Hazard Statements

Precautionary Statements

Hazard Classifications

Eye Dam. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

A new HPLC method for simultaneously measuring chloride, sugars, organic acids and alcohols in food samples
Zaky AS
J. Food Compos. Anal., 56(1-2), 25-33 (2017)
Simultaneous HPLC determination of organic acids, sugars and alcohols
Doyon G
Can. Inst. Food Sci Technol. J., 24(1-2), 87-94 (1991)
Food additives data book
Food additives data book, 56, 66-69 (2003)
Simultaneous Determination of Succinic Acid and Water-Soluble Vitamins by Ion-Pair High-Performance Liquid Chromatography
Leonov KA
Journal of Analytical Chemistry, 73(4), 358-363 (2018)
Determination of lactic, acetic, succinic, and citric acids in table olives by HPLC/UV
Cunha SC, et al.
Journal of Liquid Chromatography and Related Technologies, 24(7), 1029-1038 (2001)

Protocols

HPLC Analysis of Organic Acids Commonly Found in Wine and Beer on TSKgel® OApak-P and OApak-A

Separation of Pyruvic acid, United States Pharmacopeia (USP) Reference Standard; Tartaric acid, United States Pharmacopeia (USP) Reference Standard; Citric acid, United States Pharmacopeia (USP) Reference Standard; Malic acid, United States Pharmacopeia (USP) Reference Standard; L-Pyroglutamic acid, ≥99.0% (T); Lactic acid, United States Pharmacopeia (USP) Reference Standard; Acetic acid, ≥99.99% trace metals basis; Succinic acid, United States Pharmacopeia (USP) Reference Standard

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