All Photos(1)

Documents

PHR1421

Chlorhexidine

Name: Chlorhexidine
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

Sign Into View Organizational & Contract Pricing

All Photos(1)

Synonym(s):

Chlorhexidine, 1,1′-Hexamethylenebis[5-(4-chlorophenyl)biguanide]

Linear Formula:

[-(CH₂)₃NHC(=NH)NHC(=NH)NHC₆H₄Cl]₂

CAS Number:

55-56-1

Molecular Weight:

505.45

Beilstein:

2826432

EC Number:

200-238-7

MDL number:

MFCD00009673

PubChem Substance ID:

329823391

NACRES:

NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to Ph. Eur. C1510000
traceable to USP 1111001

API family

chlorhexidine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

134-136 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

Clc1ccc(NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)Nc2ccc(Cl)cc2)cc1

InChI

1S/C22H30Cl2N10/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34)

InChI key

GHXZTYHSJHQHIJ-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Related Categories

Analytical Reference Standards

Certified Reference Materials

Pharmacopeia & Metrological Institute Standards

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Chlorhexidine, the most popular antiseptic of biguanides, acts as a potential antimicrobial agent against several gram-positive and a few gram-negative bacteria. It is prescribed as a medicine for the prevention and treatment of the redness, swelling, and bleeding gums associated with gingivitis in humans. It may also be used as a general-purpose disinfectant for cleansing wounds, skin, instrument, and equipment in veterinary applications. Other applications of chlorhexidine include its use as the component of shampoos, ointments, skin and wound cleansers etc.

Application

Chlorhexidine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3899 in the slot below. This is an example certificate only and may not be the lot that you receive.

related product

Product No.

Description

Pricing

Signal Word

Danger

Hazard Statements

H318 - H410

Precautionary Statements

P273 - P280 - P305 + P351 + P338 - P391 - P501

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

How to Find the Product Number

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503

Product Number

25G

Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

How to Find a Lot/Batch Number for COA

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').
For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').
For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

High-performance liquid chromatographic method for the determination of chlorhexidine

Huston CE, et al.

Journal of Chromatography A, 237(3), 457-464 (1982)

HPLC determination of chlorhexidine gluconate and p-chloroaniline in topical ointment

Havlikova L, et al.

Journal of Pharmaceutical and Biomedical Analysis, 43(3), 1169-1173 (2007)

On-line post-column photochemical derivatization in liquid chromatographic− diode-array detection analysis of binary drug mixtures.

Di Pietra AM,et al

Journal of Pharmaceutical and Biomedical Analysis, 14(8-10), 1191-1199 (1996)

Automated chromatographic determination of chlorhexidine in pharmaceutical preparations

Bailey F, et al.

Journal of Chromatography A, 109(2), 305-312 (1975)

The forgotten role of alcohol: a systematic review and meta-analysis of the clinical efficacy and perceived role of chlorhexidine in skin antisepsis.

Matthias Maiwald et al.

PloS one, 7(9), e44277-e44277 (2012-09-18)

Skin antisepsis is a simple and effective measure to prevent infections. The efficacy of chlorhexidine is actively discussed in the literature on skin antisepsis. However, study outcomes due to chlorhexidine-alcohol combinations are often attributed to chlorhexidine alone. Thus, we sought

View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service