Skip to Content
Merck
CN

PHR1443

Irbesartan

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

2-Butyl-3-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C25H28N6O
CAS Number:
138402-11-6
Molecular Weight:
428.53
NACRES:
NA.24
PubChem Substance ID:
329822604
UNSPSC Code:
41116107
MDL number:
MFCD00864464

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

Irbesartan, Pharmaceutical Secondary Standard; Certified Reference Material

Gene Information

human ... AGTR1(185)

InChI

1S/C25H28N6O/c1-2-3-10-22-26-25(15-6-7-16-25)24(32)31(22)17-18-11-13-19(14-12-18)20-8-4-5-9-21(20)23-27-29-30-28-23/h4-5,8-9,11-14H,2-3,6-7,10,15-17H2,1H3,(H,27,28,29,30)

SMILES string

CCCCC1=NC2(CCCC2)C(=O)N1Cc3ccc(cc3)-c4ccccc4-c5nnn[nH]5

InChI key

YOSHYTLCDANDAN-UHFFFAOYSA-N

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. Y0001166
traceable to USP 1347700

API family

irbesartan

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Quality Level

300

Looking for similar products? Visit Product Comparison Guide

Related Categories

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Application

Irbesartan may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and combined dosage forms by chromatography and spectrophotometric techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Irbesartan is a potent, long-acting “sartan” class, nonpeptide, angiotensin II receptor antagonist utilized for the management of hypertension as well as heart failure in clinical patients. It shows high selectivity for the AT1 subtype (angiotensin I), and effectively reduces the probabilities of cardiac failure, myocardial infarction, sudden death, etc.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC2897 in the slot below. This is an example certificate only and may not be the lot that you receive.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Electrochemical determination of antihypertensive drug irbesartan in pharmaceuticals
Gupta VK, et al.
Analytical biochemistry, 410(2), 266-271 (2011)
A novel dilute and shoot HPLC assay method for quantification of irbesartan and hydrochlorothiazide in combination tablets and urine using second generation C18-bonded monolithic silica column with double gradient elution
Koyuturk S, et al.
Journal of Pharmaceutical and Biomedical Analysis, 97(2), 103-110 (2014)
Determination of hydrochlorothiazide and irbesartan in pharmaceuticals by fourth-order UV derivative spectrophotometry
Vetuschi C, et al.
Il Farmaco (Societa Chimica Italiana : 1989), 60(8), 665-670 (2005)
H-Point Standard Addition Method for Simultaneous Spectrophotometric Determination of Irbesartan, hydrochlorothiazide and Telmisartan in tablets
Sivasubramanian L and Lakshmi KS
International Journal of Research in Pharmacy and Chemistry, 4(2), 373-380 (2014)
Simultaneous determination of olmesartan medoxomil and irbesartan and hydrochlorothiazide in pharmaceutical formulations and human serum using high performance liquid chromatography
Sultana N, et al.
Se Pu / Chinese Journal of Chromatography, 26(5), 544-549 (2008)
View All Related Papers

Related Content

最新推出的满足海关审查要求的标准物质

默克Supelco®标准物质不断推出或更新满足海关及法规要求的标准物质。每年我们约有上百种的新CRM或标准物质上市，在此我们尽可能多的列出满足海关及法规要求的标准物质。

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service