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PHR1449

Supelco

Salicylamide

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):
Salicylamide, 2-Hydroxybenzamide
Linear Formula:
2-(HO)C6H4CONH2
CAS Number:
Molecular Weight:
137.14
Beilstein:
742439
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

Quality Level

grade

certified reference material
pharmaceutical secondary standard

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

140-144 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

pharmacopeia traceability

traceable to USP 1608000

storage temp.

2-30°C

SMILES string

NC(=O)c1ccccc1O

InChI

1S/C7H7NO2/c8-7(10)5-3-1-2-4-6(5)9/h1-4,9H,(H2,8,10)

InChI key

SKZKKFZAGNVIMN-UHFFFAOYSA-N

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General description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards.
Salicylamide is an antipyretic and analgesic, frequently prescribed in combination with other related drugs.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Salicylamide may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrofluorimetry, spectrophotometry and high-performance thin layer chromatography.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA2826 in the slot below. This is an example certificate only and may not be the lot that you receive.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Spectrophotometric Determination of Salicylamide and Paracetamol in Biological Samples and Pharmaceutical Formulations by a Differential Kinetic Method.
Afkhami A, et al.
Acta Chimica Slovenica, 53(3), 619-624 (2006)
Determination of salicylamide in pharmaceutical tablets by high-performance thin-layer chromatography with ultraviolet absorption densitometry.
Sullivan C and Sherma J
Acta Chromatographica , 16(3), 153-163 (2006)
A simple solid phase spectrofluorimetric method combined with flow analysis for the rapid determination of salicylamide and salicylic acid in pharmaceutical samples.
Medina AR, et al.
Fresenius Journal of Analytical Chemistry, 365(7), 619-624 (1999)
Saura C Sahu et al.
Journal of applied toxicology : JAT, 34(11), 1155-1166 (2014-02-14)
The use of silver nanoparticles in food, food contact materials, dietary supplements and cosmetics has increased significantly owing to their antibacterial and antifungal properties. As a consequence, the need for validated rapid screening methods to assess their toxicity is necessary

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