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PHR1516

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Glycyrrhizic Acid

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
Glycyrrhizic acid, GL, 3-O-(2-O-β-D-Glucopyranuronosyl-α-D-glucopyranuronosyl)-18β-glycyrrhetinic acid, Glycyrrhetinic acid glycoside, Glycyrrhizinic acid
Empirical Formula (Hill Notation):
C42H62O16
CAS Number:
1405-86-3
Molecular Weight:
822.93
MDL number:
MFCD00065194

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to USP 1295888

API family

glycyrrhizic acid

CofA

current certificate can be downloaded

packaging

pkg of 200 mg

application(s)

pharmaceutical

format

neat

storage temp.

2-8°C

SMILES string

C[C@]1(C(O)=O)CC[C@@](CC[C@]([C@@]2(C)[C@@]3([H])[C@]4(C)[C@@](C(C)(C)[C@@H](O[C@@]5([H])O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]5O[C@@]6([H])[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O6)CC4)([H])CC2)(C)C7=CC3=O)(C)[C@@]7([H])C1

InChI

1S/C42H62O16/c1-37(2)21-8-11-42(7)31(20(43)16-18-19-17-39(4,36(53)54)13-12-38(19,3)14-15-41(18,42)6)40(21,5)10-9-22(37)55-35-30(26(47)25(46)29(57-35)33(51)52)58-34-27(48)23(44)24(45)28(56-34)32(49)50/h16,19,21-31,34-35,44-48H,8-15,17H2,1-7H3,(H,49,50)(H,51,52)(H,53,54)/t19-,21-,22-,23-,24-,25-,26-,27+,28-,29-,30+,31+,34-,35-,38+,39-,40-,41+,42+/m0/s1

InChI key

LPLVUJXQOOQHMX-QWBHMCJMSA-N

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General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Application

Glycyrrhizic Acid may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography and electroanalytical techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB5518 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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HPLC-DAD-Q-TOF-MS/MS analysis and HPLC quantitation of chemical constituents in traditional Chinese medicinal formula Ge-Gen Decoction.
Yan Y, et al.
Journal of Pharmaceutical and Biomedical Analysis, 80(1), 192-202 (2001)
Determination of 14 chemical constituents in the traditional Chinese medicinal preparation Huangqin-Tang by high performance liquid chromatography.
Zuo F, et al.
Biological & Pharmaceutical Bulletin, 24(6), 693-697 (2001)
Quality control of a herbal medicinal preparation using high-performance liquid chromatographic and capillary electrophoretic methods.
Chen J, et al.
Journal of Pharmaceutical and Biomedical Analysis, 55(1), 206-210 (2011)
Zhen Wang et al.
Oncogenesis, 9(9), 82-82 (2020-09-19)
Triple-negative breast cancer (TNBC) is highly aggressive, difficult to treat and commonly develops visceral metastasis, including lung metastasis. We observed that High mobility group box 1 protein (HMGB1) was highly expressed in human TNBC and positively correlated with cancer metastasis.

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