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PHR1570

Mesna

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Sodium 2-mercaptoethanesulfonate, 2-Mercaptoethanesulfonic acid sodium salt, Coenzyme M sodium salt, HS-CoM Na, MESNA

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About This Item

Linear Formula:
HSCH2CH2SO3Na
CAS Number:
19767-45-4
Molecular Weight:
164.18
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823479
EC Number:
243-285-9
Beilstein/REAXYS Number:
3657828
MDL number:
MFCD00007535

Key Documents

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InChI key

XOGTZOOQQBDUSI-UHFFFAOYSA-M

InChI

1S/C2H6O3S2.Na/c3-7(4,5)2-1-6;/h6H,1-2H2,(H,3,4,5);/q;+1/p-1

SMILES string

[Na+].[O-]S(=O)(=O)CCS

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. Y0000337, traceable to USP 1392807

API family

mesna

CofA

current certificate can be downloaded

packaging

pkg of 500 mg

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Quality Level

300

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Mesna may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography and electroanalytical techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA4486 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Current applications of miniaturized chromatographic and electrophoretic techniques in drug analysis.
Aturki Z, et al.
Journal of Pharmaceutical and Biomedical Analysis, 101, 194-220 (2014)
Potentiometric behaviour of ion selective electrodes based on iron porphyrins: The influence of porphyrin substituents on the response properties and analytical determination of diclofenac in pharmaceutical formulations.
Santos E, et al.
Journal of Pharmaceutical and Biomedical Analysis, 42(5), 535-542 (2006)
Validated stability-indicating HPLC method for the determination of mesna in presence of its degradation products.
Rizk M, et al.
Journal of Chromatographic Science, 53(5), 742-748 (2014)

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