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PHR1572

Supelco

Oxymetazoline Hydrochloride

certified reference material, pharmaceutical secondary standard

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Synonym(s):
Oxymetazoline hydrochloride, 2-(3-Hydroxy-2,6-dimethyl-4-t-butylbenzyl)-2-imidazoline hydrochloride
Empirical Formula (Hill Notation):
C16H24N2O · HCl
CAS Number:
2315-02-8
Molecular Weight:
296.84
EC Number:
219-015-0
MDL number:
MFCD00058147
PubChem Substance ID:
329823480

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to Ph. Eur. O0290000
traceable to USP 1486004

API family

oxymetazoline

CofA

current certificate can be downloaded

packaging

pkg of 10 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

Cl.Cc1cc(c(O)c(C)c1CC2=NCCN2)C(C)(C)C

InChI

1S/C16H24N2O.ClH/c1-10-8-13(16(3,4)5)15(19)11(2)12(10)9-14-17-6-7-18-14;/h8,19H,6-7,9H2,1-5H3,(H,17,18);1H

InChI key

BEEDODBODQVSIM-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRA2A(150) , ADRA2B(151) , ADRA2C(152)

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General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Oxymetazoline hydrochloride belongs to the category of non-selective adrenergic drugs commonly used as eye and nose drops.

Application

Oxymetazoline hydrochloride may be used as a pharmaceutical secondary standard for the determination of the analyte in pharmaceutical formulations using spectrophotometric technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Oxymetazoline hydrochloride is a partial α2A-adrenoceptor agonist; agonist at 5-HT1A, 5-HT1B, and 5-HT1D serotonin receptors. It is a mixed agonist-antagonist at 5-HT1C serotonin receptors.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB5024 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

related product

Product No.
Description
Pricing

Y0001044

Oxymetazoline impurity A, European Pharmacopoeia (EP) Reference Standard

O0290000

Oxymetazoline hydrochloride, European Pharmacopoeia (EP) Reference Standard

1486015

Oxymetazoline Related Compound A, United States Pharmacopeia (USP) Reference Standard

43329

2-(4-tert-Butyl-3-hydroxy-2,6-dimethylphenyl)acetamide, reference material

PHR2215

Oxymetazoline Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material

PHR9134

2-(4-tert-Butyl-3-hydroxy-2,6-dimethylphenyl)acetic acid, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

PHR9161

2-(4-tert-Butyl-3-hydroxy-2,6-dimethylphenyl)acetonitrile, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

Pictograms

CorrosionSkull and crossbones
GHS05,GHS06

Signal Word

Danger

Hazard Statements

H300 + H330 - H318 - H412

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Aquatic Chronic 3 - Eye Dam. 1

Storage Class Code

6.1B - Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Regulatory Information

监管及禁止进口产品

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Spectrophotometric determination of oxymetazoline hydrochloride based on the oxidation reactions
Al-Sabha NT and Rasheed AB
Jordan Journal of Chemistry, 146(605), 1-9 (2011)

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